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ArticleInternational journal of stroke : official journal of the International Stroke Society2024

Stroke characteristics and outcomes in urban Tanzania: Data from the Prospective Lake Zone Stroke Registry.

Sarah Shali Matuja, Joshua Ngimbwa, Lilian Andrew, Jemima Shindika, Goodluck Nchasi, Anna Kasala, Innocent Kitandu Paul, Mary Ndalahwa, Akili Mawazo, Fredrick Kalokola and 20 more

Registry-linked trialAbstract read
In one paragraph

Article in International journal of stroke : official journal of the International Stroke Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07207330 (Stroke Code), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07207330 recruitingnot on this mapstarted 2025, after this paper: background citation

Stroke Code: an Observational Cross-sectional Trial in Hospitals From Villavicencio, Colombia

TypeobservationalSponsorHospital Departamental de VillavicencioRan2025 to 2027Enrolled100ConditionsStroke, Ischemic Stroke
3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

30 authors.

Sarah Shali MatujaDepartment of Internal Medicine, Weill Bugando School of Medicine, Catholic University of Health and Allied Sciences, Mwanza, Tanzania.ORCID 0000-0001-7329-3922
Joshua NgimbwaDepartment of Internal Medicine, Bugando Medical Centre, Mwanza, Tanzania.
Lilian AndrewDepartment of Internal Medicine, Bugando Medical Centre, Mwanza, Tanzania.
Jemima ShindikaDepartment of Internal Medicine, Bugando Medical Centre, Mwanza, Tanzania.
Goodluck NchasiDepartment of Internal Medicine, Weill Bugando School of Medicine, Catholic University of Health and Allied Sciences, Mwanza, Tanzania.
Anna KasalaDepartment of Internal Medicine, Weill Bugando School of Medicine, Catholic University of Health and Allied Sciences, Mwanza, Tanzania.
Innocent Kitandu PaulDepartment of Internal Medicine, Weill Bugando School of Medicine, Catholic University of Health and Allied Sciences, Mwanza, Tanzania.
Mary NdalahwaDepartment of Internal Medicine, Weill Bugando School of Medicine, Catholic University of Health and Allied Sciences, Mwanza, Tanzania.
Akili MawazoDepartment of Microbiology and Immunology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.
Fredrick KalokolaDepartment of Internal Medicine, Weill Bugando School of Medicine, Catholic University of Health and Allied Sciences, Mwanza, Tanzania.
Patrick NgoyaDepartment of Internal Medicine, Weill Bugando School of Medicine, Catholic University of Health and Allied Sciences, Mwanza, Tanzania.
Ladius RudovickDepartment of Internal Medicine, Weill Bugando School of Medicine, Catholic University of Health and Allied Sciences, Mwanza, Tanzania.
Semvua KilonzoDepartment of Internal Medicine, Weill Bugando School of Medicine, Catholic University of Health and Allied Sciences, Mwanza, Tanzania.
Bahati WajangaDepartment of Internal Medicine, Weill Bugando School of Medicine, Catholic University of Health and Allied Sciences, Mwanza, Tanzania.
Fabian MassagaDepartment of Internal Medicine, Weill Bugando School of Medicine, Catholic University of Health and Allied Sciences, Mwanza, Tanzania.
Samuel E KalluvyaDepartment of Internal Medicine, Weill Bugando School of Medicine, Catholic University of Health and Allied Sciences, Mwanza, Tanzania.
Patricia MunseriDepartment of Internal Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.ORCID 0000-0002-8754-2755
Mohamed A MnachoDepartment of Internal Medicine, Muhimbili National Hospital, Dar es Salaam, Tanzania.
Kigocha Okeng'oDepartment of Internal Medicine, Muhimbili National Hospital, Dar es Salaam, Tanzania.
Henrika KimamboDepartment of Internal Medicine, Muhimbili National Hospital, Dar es Salaam, Tanzania.
Mohamed ManjiDepartment of Internal Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania.ORCID 0000-0001-8837-0230
Paschal RuggajoDepartment of Curative Services, Ministry of Health, Community Development, Gender, Elderly and Children, Dodoma, Tanzania.
Tumaini NaguMinistry of Health, Community Development, Gender, Elderly and Children, Dodoma, Tanzania.
Rashid Ali AhmedDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Faheem SheriffDepartment of Neurology, Paul L. Foster School of Medicine, Texas Tech University Health Sciences Center, El Paso, TX, USA.
Karim MahawishStroke Medicine Department, Counties Manukau Health, Auckland, New Zealand.ORCID 0000-0003-2256-6470
Halinder MangatDivision of Neurocritical Care, Department of Neurology, The University of Kansas Medical Center, Kansas City, KS, USA.ORCID 0000-0003-3426-2001
Mai N Nguyen-HuynhDivision of Research, The Permanente Medical Group, Kaiser Permanente Northern California, Oakland, CA, USA.
Deanna SaylorDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Robert PeckDepartment of Internal Medicine, Weill Bugando School of Medicine, Catholic University of Health and Allied Sciences, Mwanza, Tanzania.

Funding

Vanderbilt-Emory-Cornell-Duke Global Health Fellowship Consortium-Expanding Diversity for Global Equity (EDGE)D43TW009337 · FIC · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ALIYU, MUKTAR HASSAN, HEIMBURGER, DOUGLAS CORBETT · 2017 to 2021
$6.3M
HIV, Sleep, Nocturnal Non-dipping, and Cardiovascular Disease: a Tanzanian CohortR01HL160332 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI PECK, ROBERT N · 2021 to 2025
$2.7M
Patient-Oriented Research in Global Cardiovascular Diseases and Interactions with HIVK24HL170902 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI Robert N Peck · 2023 to 2026
$504k
FIC NIH HHS D43 TW009337NHLBI NIH HHS K24 HL170902NHLBI NIH HHS R01 HL160332
6 · The paper itself

Abstract

backgroundStroke is a second leading cause of death globally, with an estimated one in four adults suffering a stroke in their lifetime. We aimed to describe the clinical characteristics, quality of care, and outcomes in adults with stroke in urban Northwestern Tanzania.

methodsWe analyzed de-identified data from a prospective stroke registry from Bugando Medical Centre in Mwanza, the second largest city in Tanzania, between March 2020 and October 2022. This registry included all adults ⩾18 years admitted to our hospital who met the World Health Organization clinical definition of stroke. Information collected included demographics, risk factors, stroke severity using the National Institutes of Health Stroke Scale, brain imaging, indicators for quality of care, discharge modified Rankin Scale, and in-hospital mortality. We examined independent factors associated with mortality using logistic regression.

resultsThe cohort included 566 adults, of which 52% (294) were female with a mean age of 65 ± 15 years. The majority had a first-ever stroke 88% (498). Premorbid hypertension was present in 86% (488) but only 41% (200) were taking antihypertensive medications before hospital admission; 6% (32) had HIV infection. Ischemic strokes accounted for 66% (371) but only 6% (22) arriving within 4.5 h of symptom onset. In-hospital mortality was 29% (127). Independent factors associated with mortality were severe stroke (adjusted odds ratio (aOR) = 1.81, 95% confidence interval (CI) = 1.47-2.24, p < 0.001), moderate to severe stroke (aOR = 1.49, 95% CI = 1.22-1.84, p < 0.001), moderate stroke (aOR = 1.80, 95% CI = 1.52-2.14, p < 0.001), leukocytosis (aOR = 1.19, 95% CI = 1.03-1.38, p = 0.022), lack of health insurance coverage (aOR = 1.15, 95% CI = 1.02-1.29, p = 0.025), and not receiving any form of venous thromboembolism prophylaxis (aOR = 1.18, 95% CI = 1.02-1.37, p = 0.027).

conclusionWe report a stroke cohort with poor in-hospital outcomes in urban Northwestern Tanzania. Early diagnosis and treatment of hypertension could prevent stroke in this region. More work is needed to raise awareness about stroke symptoms and to ensure that people with stroke receive guidelines-directed therapy.

Indexed as

Hospital MortalityRegistriesStrokeAdultAgedAged, 80 and overFemaleHumansHypertensionMaleMiddle AgedProspective StudiesRisk FactorsTanzaniaUrban PopulationmorbiditymortalityStrokestroke registriesTanzania

Identifiers

PMID38031727
PMCPMC11132936

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