Evidence map›Paper›PMID 38031651›Full record

ArticleJournal of veterinary science2023

Subcutaneous

Ran An, Yongli Guo, Mingchun Gao, Junwei Wang

Open access · goldAbstract read
In one paragraph

Article in Journal of veterinary science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. TargetingVaccines · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Ran AnHeilongjiang Provincial Key Laboratory of Zoonosis, Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northeast Agricultural University, Harbin 150000, China.ORCID https://orcid.org/0000-0001-8744-3266
Yongli GuoDepartment of Immunology, Heilongjiang Provincial Key Laboratory for Infection and Immunity, Harbin Medical University, Harbin 150000, China.ORCID https://orcid.org/0000-0002-1243-7336
Mingchun GaoHeilongjiang Provincial Key Laboratory of Zoonosis, Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northeast Agricultural University, Harbin 150000, China. gaomingchun@neau.edu.cn.ORCID https://orcid.org/0000-0001-8782-6080
Junwei WangHeilongjiang Provincial Key Laboratory of Zoonosis, Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northeast Agricultural University, Harbin 150000, China. jwwang@neau.edu.cn.ORCID https://orcid.org/0000-0002-5674-6464
Northeast Agricultural University · CNHarbin Medical University · CN

Funding

China Agriculture Research System CARS36
6 · The paper itself

Abstract

backgroundGlyceraldehyde-3-phosphate dehydrogenase (GAPDH) on the surface of

objectiveThis study assessed GAPDH as a potential immunization candidate protein to prevent streptococcus infections.

methodsMice were vaccinated subcutaneously with recombinant GAPDH and challenged with

resultsVaccination with rGAPDH improved the survival rates and decreased the bacterial burdens in the mammary glands compared to the control group. The mechanism by which rGAPDH vaccination protects against

conclusionsGAPDH is a promising immunization candidate protein for targeting virulence and enhancing immune-mediated protection. Further investigations are warranted to understand the mechanisms underlying the activation of BMDCs by rGAPDH in a TLR2- and TLR4-dependent manner and the regulation of inflammatory cytokines contributing to mastitis pathogenesis.

Indexed as

Toll-Like Receptor 4VaccinesAnimalsCytokinesFemaleGlyceraldehyde-3-Phosphate DehydrogenasesImmunity, InnateImmunologic FactorsMiceStreptococcusToll-Like Receptor 2CytokinesGlyceraldehyde-3-Phosphate DehydrogenasesImmunologic FactorsToll-Like Receptor 2Toll-Like Receptor 4VaccinesBMDCsGAPDHIL-10intramammary infectionStreptococcus dysgalactiae

Identifiers

PMID38031651
PMCPMC10556295
OpenAlexW4386516499

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.