Evidence map›Paper›PMID 38031646›Full record

ArticleJournal of veterinary science2023

Biochemical and structural comparisons of non-nucleoside reverse transcriptase inhibitors against feline and human immunodeficiency viruses.

Siriluk Rattanabunyong, Khuanjarat Choengpanya, Chonticha Suwattanasophon, Duangnapa Kiriwan, Peter Wolschann, Thomanai Lamtha, Abdul Rajjak Shaikh, Jatuporn Rattanasrisomporn, Kiattawee Choowongkomon

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of veterinary science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Siriluk Rattanabunyong *Department of Biochemistry, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand.ORCID https://orcid.org/0000-0003-1078-186X
Khuanjarat Choengpanya *Program in Basic Science, Maejo University-Phrae Campus, Phrae 54140, Thailand.ORCID https://orcid.org/0000-0002-3183-8928
Chonticha SuwattanasophonDepartment of Physiological Chemistry, Faculty of Chemistry, University of Vienna, Vienna 1090, Austria.ORCID https://orcid.org/0000-0002-7020-3300
Duangnapa KiriwanDepartment of Biochemistry, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand.ORCID https://orcid.org/0000-0003-4824-7398
Peter WolschannInstitute for Theoretical Chemistry, Faculty of Chemistry, University of Vienna, Vienna 1090, Austria.ORCID https://orcid.org/0000-0001-6104-6596
Thomanai LamthaDepartment of Biochemistry, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand.ORCID https://orcid.org/0000-0001-5918-8704
Abdul Rajjak ShaikhDepartment of Biochemistry, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand.ORCID https://orcid.org/0000-0003-4444-0684
Jatuporn RattanasrisompornDepartment of Companion Animal Clinical Sciences, Faculty of Veterinary Medicine, Kasetsart University, Bangkok 10900, Thailand.ORCID https://orcid.org/0000-0002-2426-0961
Kiattawee ChoowongkomonDepartment of Biochemistry, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand.ORCID https://orcid.org/0000-0002-2421-7859

Funding

Kasetsart University Reinventing University ProgramKasetsart University Research and Development Institute FF (KU)17.64Office of the Ministry of Higher Education, Science, Research and Innovation
6 · The paper itself

Abstract

backgroundFeline immunodeficiency virus (FIV) causes an acquired immunodeficiency-like syndrome in cats. FIV is latent. No effective treatment has been developed for treatment the infected cats. The first and second generations non-nucleoside reverse transcriptase inhibitors (NNRTIs) for HIV treatment, nevirapine (NVP) and efavirenz (EFV), and rilpivirine (RPV), were used to investigate the potential of NNRTIs for treatment of FIV infection.

objectiveThis study aims to use experimental and

methodsThe FIV-RT and human immunodeficiency virus reverse transcriptase (HIV-RT) were expressed and purified using chromatography approaches. The purified proteins were used to determine the IC

resultsThe IC

conclusionsOur results suggest the first and second generation NNRTIs (NVP, EFV, and RPV) could inhibit both FIV-RT and HIV-RT.

Indexed as

Anti-HIV AgentsCat DiseasesHIV-1HIV InfectionsAnimalsCatsHIV Reverse TranscriptaseHumansMolecular Docking SimulationNevirapineReverse Transcriptase InhibitorsRilpivirineAnti-HIV AgentsHIV Reverse TranscriptaseNevirapineReverse Transcriptase InhibitorsRilpivirineefavirenzFIVHIVnevirapineNNRTIrilpivirine

Identifiers

PMID38031646
PMCPMC10556290

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.