Evidence map›Paper›PMID 38031358›Full record

ArticleNeurogastroenterology and motility2024

Neural correlates of perceived and relative resilience in male and female patients with irritable bowel syndrome.

Lisa A Kilpatrick, Arpana Gupta, Kirsten Tillisch, Jennifer S Labus, Bruce D Naliboff, Emeran A Mayer, Lin Chang

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurogastroenterology and motility, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Role of Sex, Anxiety, and Resilience in the Association Between Adverse Childhood Experiences and Irritable Bowel Syndrome.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Lisa A KilpatrickGoodman-Luskin Microbiome Center, David Geffen School of Medicine, University of California, Los Angeles, California, USA.ORCID https://orcid.org/0000-0003-2148-5214
Arpana GuptaGoodman-Luskin Microbiome Center, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
Kirsten TillischGoodman-Luskin Microbiome Center, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
Jennifer S LabusGoodman-Luskin Microbiome Center, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
Bruce D NaliboffGoodman-Luskin Microbiome Center, David Geffen School of Medicine, University of California, Los Angeles, California, USA.ORCID https://orcid.org/0000-0003-0959-8670
Emeran A MayerGoodman-Luskin Microbiome Center, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
Lin ChangGoodman-Luskin Microbiome Center, David Geffen School of Medicine, University of California, Los Angeles, California, USA.ORCID https://orcid.org/0000-0001-6800-2967
University of California, Los Angeles · US

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Women's Health and Functional Visceral Disorders CenterP50DK064539 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MAYER, EMERAN A · 2002 to 2017
$17.5M
The role of brain-gut microbiome interactions in mediating IBS and constipation symptoms during menses and menopauseU54DK123755 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Lin Chang, Elaine Hsiao · 2020 to 2026
$10.5M
Neurobiological endophenotypes & gene-environment interactions in IC/PBS & in aU01DK082370 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KUTCH, JASON J., MAYER, EMERAN A · 2008 to 2021
$9.2M
PERCEPTION AND MODULATION OF VISCERAL SENSATIONSR01DK048351 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MAYER, EMERAN A · 1996 to 2019
$8.2M
Neuroimaging biomarkers of Mind-Body treatment response in chronic visceral painR01AT007137 · NCCIH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI NALIBOFF, BRUCE D, TILLISCH, KIRSTEN · 2011 to 2015
$2.7M
Role of Inflammatory Processes in Reward Network Alterations in ObesityK23DK106528 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHURCH, ARPANA · 2016 to 2020
$1.0M
Role of the Gut Microbiome in Reward Network Alterations in ObesityR03DK121025 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHURCH, ARPANA · 2020 to 2021
$234k
NCATS NIH HHS UL1 TR001881NCCIH NIH HHS R01 AT007137NIDDK NIH HHS K23 DK106528NIDDK NIH HHS P50 DK064539NIDDK NIH HHS R01 DK048351NIDDK NIH HHS R03 DK121025NIDDK NIH HHS U01 DK082370NIDDK NIH HHS U54 DK123755NIH HHS
6 · The paper itself

Abstract

backgroundPatients with irritable bowel syndrome (IBS) show lower resilience than healthy controls (HCs), associated with greater symptom severity and worse quality of life. However, little is known about affected markers of resilience or the influence of sex. Furthermore, as resilience is complex, a comprehensive assessment, with multiple resilience measures, is needed. Therefore, we aimed to evaluate perceived and relative resilience and their neural correlates in men and women with IBS.

methodsIn 402 individuals (232 IBS [73.3% women] and 170 HCs [61.2% women]), perceived resilience was assessed by the Connor-Davidson Resilience Scale (CDRISC) and Brief Resilience Scale (BRS); relative resilience was assessed by the standardized residual of the Short Form-12 mental component summary score predicted by the Adverse Childhood Experiences score. Non-rotated partial least squares analysis of region-to-region resting-state connectivity data was used to define resilience-related signatures in HCs. Disease and sex-related differences within these signatures were investigated. KEY

resultsScores on all resilience measures were lower in IBS than in HCs (p's < 0.05). In all three resilience-related signatures, patients with IBS showed reduced connectivity largely involving the central autonomic network (p's < 0.001). Men with IBS showed lower CDRISC scores than women with IBS, and greater reductions in CDRISC-related connectivity, associated with worse symptom severity (p < 0.05). CONCLUSIONS AND INFERENCES: Individuals with IBS show reduced perceived and relative resilience, with reduced connectivity suggesting impaired homeostasis maintenance. Men with IBS may show additional impairment in specific aspects of resilience. Treatments aimed at improving resilience may benefit patients with IBS, especially men with IBS.

Indexed as

Irritable Bowel SyndromePsychological TestsResilience, PsychologicalFemaleHumansMaleQuality of LifeSeverity of Illness Indexfunctional magnetic resonance imagingirritable bowel syndromepsychological resiliencesex differences

Identifiers

PMID38031358
PMCPMC11014739
OpenAlexW4389179819

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.