Evidence map›Paper›PMID 38031130›Full record

ArticleBMC veterinary research2023

Corynebacterium oculi-related bacterium may act as a pathogen and carrier of antimicrobial resistance genes in dogs: a case report.

Milena Tresch, Christine Watté, Michele Stengard, Corinne Ritter, Isabelle Brodard, Simon Feyer, Estelle Gohl, Ezgi Akdesir, Vincent Perreten, Sonja Kittl

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC veterinary research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Milena TreschInstitute of Veterinary Bacteriology, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
Christine WattéDepartment of Clinical Veterinary Medicine, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
Michele StengardDepartment of Clinical Veterinary Medicine, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
Corinne RitterCabinet Vétérinaire Villereuse, Geneva, Switzerland.
Isabelle BrodardInstitute of Veterinary Bacteriology, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
Simon FeyerInstitute of Veterinary Bacteriology, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
Estelle GohlInstitute of Veterinary Bacteriology, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
Ezgi AkdesirInstitute of Veterinary Bacteriology, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
Vincent PerretenInstitute of Veterinary Bacteriology, Vetsuisse Faculty, University of Bern, Bern, Switzerland.
Sonja KittlInstitute of Veterinary Bacteriology, Vetsuisse Faculty, University of Bern, Bern, Switzerland. sonja.kittl@unibe.ch.
University of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe genus Corynebacterium comprises well-known animal and human pathogens as well as commensals of skin and mucous membranes. Species formerly regarded as contaminants are increasingly being recognized as opportunistic pathogens. Corynebacterium oculi has recently been described as a human ocular pathogen but has so far not been reported in dogs. CASE PRESENTATION: Here we present two cases of infection with a novel Corynebacterium sp., a corneal ulcer and a case of bacteriuria. The two bacterial isolates could not be identified by MALDI-TOF MS. While 16 S rRNA gene (99.3% similarity) and rpoB (96.6% identity) sequencing led to the preliminary identification of the isolates as Corynebacterium (C.) oculi, whole genome sequencing revealed the strains to be closely related to, but in a separate cluster from C. oculi. Antimicrobial susceptibility testing showed high minimal inhibitory concentrations of lincosamides, macrolides, tetracycline, and fluoroquinolones for one of the isolates, which also contained an erm(X) and tet-carrying plasmid as well as a nonsynonymous mutation leading to an S84I substitution in the quinolone resistance determining region of GyrA.

conclusionsWhile the clinical signs of both dogs were alleviated by antimicrobial treatment, the clinical significance of these isolates remains to be proven. However, considering its close relation with C. oculi, a known pathogen in humans, pathogenic potential of this species is not unlikely. Furthermore, these bacteria may act as reservoir for antimicrobial resistance genes also in a One Health context since one strain carried a multidrug resistance plasmid related to pNG3 of C. diphtheriae.

Indexed as

Corynebacterium InfectionsDog DiseasesAnimalsAnti-Bacterial AgentsCorynebacteriumDogsDrug Resistance, BacterialMicrobial Sensitivity TestsAnti-Bacterial AgentsCorynebacterium oculiCystitisFluoroquinolonesKeratitisMLSB

Identifiers

PMID38031130
PMCPMC10763336
OpenAlexW4389144987

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.