Evidence map›Paper›PMID 38031036›Full record

ArticleBMC biotechnology2023

The transcriptional factor Clr-5 is involved in cellulose degradation through regulation of amino acid metabolism in Neurospora crassa.

Fanglei Xue, Zhen Zhao, Shuying Gu, Meixin Chen, Jing Xu, Xuegang Luo, Jingen Li, Chaoguang Tian

Open access · goldAbstract read
In one paragraph

Article in BMC biotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Transcription Factors in Biocontrol Fungi.Journal of fungi (Basel, Switzerland) · 2025
    Review
  7. Two ZnApplied and environmental microbiology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Fanglei Xue *College of Biotechnology, Tianjin University of Science and Technology, Tianjin, 300457, China.
Zhen Zhao *Key Laboratory of Engineering Biology for Low-Carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China.
Shuying GuKey Laboratory of Engineering Biology for Low-Carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China.
Meixin ChenCollege of Biotechnology, Tianjin University of Science and Technology, Tianjin, 300457, China.
Jing XuKey Laboratory of Engineering Biology for Low-Carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China.
Xuegang LuoCollege of Biotechnology, Tianjin University of Science and Technology, Tianjin, 300457, China.
Jingen LiKey Laboratory of Engineering Biology for Low-Carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China. li_jg@tib.cas.cn.
Chaoguang TianKey Laboratory of Engineering Biology for Low-Carbon Manufacturing, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China. tian_cg@tib.cas.cn.
Chinese Academy of Sciences · CNTianjin Institute of Industrial Biotechnology · CNTianjin University of Science and Technology · CN

Funding

Guangxi Science and Technology Major Program Guike-AA22117013Key Project of the Ministry of Science and Technology of China 2018YFA0901400the Innovation fund of Haihe Laboratory of Synthetic Biology 22HHSWSS00014the Key research and development project of China National Tobacco Corporation 110202202004the project of Key Laboratory of Tobacco Processing of Zhengzhou Tobacco Research Institute of CNTC 202022AWCX02Tianjin Synthetic Biotechnology Innovation Capacity Improvement Project TSBICIP-KJGG-015Youth Innovation Promotion Association of the Chinese Academy of Sciences 2020183
6 · The paper itself

Abstract

backgroundFilamentous fungi are efficient degraders of plant biomass and the primary producers of commercial cellulolytic enzymes. While the transcriptional regulation mechanisms of cellulases have been continuously explored in lignocellulolytic fungi, the induction of cellulase production remains a complex multifactorial system, with several aspects still largely elusive.

resultsIn this study, we identified a Zn

conclusionsThese findings regarding the novel transcription factor Clr-5 enhance our comprehension of the regulatory connections between amino acid metabolism and cellulase production, offering fresh prospects for the development of fungal cell factories dedicated to cellulolytic enzyme production in bio-refineries.

Indexed as

CellulaseCellulasesNeurospora crassaCelluloseFungal ProteinsGene Expression Regulation, FungalHistidineLeucineNitrogenTranscription FactorsCellulaseCellulasesCelluloseFungal ProteinsHistidineLeucineNitrogenTranscription FactorsAmino acid metabolismCellulase productionClr-5Neurospora crassaTranscription factor

Identifiers

PMID38031036
PMCPMC10687990
OpenAlexW4389136730

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.