ArticleBMC microbiology2023
Identification of hypervirulent Klebsiella pneumoniae based on biomarkers and Galleria mellonella infection model.
Article in BMC microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Molecular Insights Into Hypervirulent Klebsiella pneumoniae: Identification and Correlation of Virulence Determinant.MicrobiologyOpen · 2026Article
- First reported Pseudomonas soli bloodstream infection confirmed by whole-genome sequencing after MALDI-TOF misidentification.BMC microbiology · 2026Article
- Genomic Characterisation of Antimicrobial Resistance and Virulence of Animal-DerivedAntibiotics (Basel, Switzerland) · 2026Article
- Emergence and Genomic Characterization of a Hypervirulent Klebsiella pneumoniae Isolate From a New Clone in Brazil.Microbiology and immunology · 2026Article
- Detection of hypervirulence genes in carbapenem resistant Klebsiella pneumoniae from cancer patients at a tertiary referral hospital in Nepal.BMC infectious diseases · 2026Article
- Mechanistic insights into the inhibitory effects of eukaryotically expressed Sarcotoxin II 50 onMicrobiology spectrum · 2026Article
- Deciphering the genomic landscape of hypervirulent Klebsiella pneumoniae in South African tertiary hospitals.BMC microbiology · 2026Article
- Plasmid-mediated convergence of multidrug resistance and hypervirulence in community-acquired Klebsiella pneumoniae in Tianjin, China.BMC microbiology · 2026Article
- Under-diagnosed hypermucoviscousIJID regions · 2026Review
- A combined genetic and phenotypic marker approach enables precise detection of hypervirulentMicrobiology spectrum · 2026Article
- Article
- Carbapenem-resistant hypervirulentFrontiers in microbiology · 2026Review
- Emergence of a multidrug-resistantFrontiers in cellular and infection microbiology · 2026Article
- Emergence of a carbapenem-resistantFrontiers in cellular and infection microbiology · 2026Article
- Establishment ofFrontiers in microbiology · 2026Article
- Coexistence of carbapenemase and hypervirulence-associated genes amongFrontiers in microbiology · 2026Article
- First report of a urinaryFrontiers in microbiology · 2026Article
- Epidemiological characterization of chromosome-mediated colistin resistance in hypervirulent carbapenem-resistant Klebsiella pneumoniae.BMC microbiology · 2025Article
- Epidemiological Investigation on Pathogenic Bacteria of Buffalo Subclinical Mastitis and Their Antibiotic Resistance and Virulence Characteristics in Guangxi, China.Animals : an open access journal from MDPI · 2025Article
- Genomic Characterization of a Rare K30-ST198 HypervirulentInternational journal of molecular sciences · 2025Article
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Authors and funding
7 authors.
Funding
Abstract
backgroundCurrently, clinical laboratories lack an effective method to differentiate between classical Klebsiella pneumoniae (cKP) and hypervirulent Klebsiella pneumoniae (hvKP) strains, leading to delays in diagnosing and treating hvKP infections. Previous studies have identified peg-344, iroB, iucA,
resultsAccording to the clinical data, a total of 108 strains of hvKP were preliminary screened. Among them, 94 strains were further identified using PCR analysis of biomarkers and quantitative determination of SP. The high virulence of hvKP was subsequently confirmed through infection experiments on Galleria mellonella. Additionally, susceptibility testing revealed the identification of 58 carbapenem-resistant hvKP (CR-hvKP) strains and 36 carbapenem-sensitive hvKP (CS-hvKP) strains. By comparing molecular diagnostic indexes, molecular characteristics such as high SP production of CR-hvKP were found.
conclusionThe combination of clinical data and molecular diagnostic index analysis effectively enables the identification of hvKP, particularly CR-hvKP. This study provides a scientific basis for accurate clinical identification and timely treatment of hvKP.
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