Evidence map›Paper›PMID 38030947›Full record

SynthesisRheumatology international2024

Quality of reporting and nature of harms in clinical trials on supervised exercise in patients with rheumatoid arthritis or axial spondyloarthritis.

Max M H Teuwen, Thea P M Vliet Vlieland, Salima F E van Weely, Jan W Schoones, Anne-Kathrin Rausch Osthoff, Carsten B Juhl, Karin Niedermann, Maaike G J Gademan, Cornelia H M van den Ende

Open access · greenAbstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Rheumatology international, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Trial
  2. Teaching evidence-based principles in Rheumatology.Rheumatology international · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Max M H TeuwenDepartment of Orthopaedics, Rehabilitation and Physical Therapy, Leiden University Medical Center, Albinusdreef 2, P.O. Box 9600, 2300 RC, Leiden, The Netherlands. m.m.h.teuwen@lumc.nl.ORCID 0000-0002-3235-7800
Thea P M Vliet VlielandDepartment of Orthopaedics, Rehabilitation and Physical Therapy, Leiden University Medical Center, Albinusdreef 2, P.O. Box 9600, 2300 RC, Leiden, The Netherlands.ORCID 0000-0001-6322-3859
Salima F E van WeelyDepartment of Orthopaedics, Rehabilitation and Physical Therapy, Leiden University Medical Center, Albinusdreef 2, P.O. Box 9600, 2300 RC, Leiden, The Netherlands.ORCID 0000-0001-8560-4687
Jan W SchoonesDirectorate of Research Policy, Leiden University Medical Center, Leiden, The Netherlands.ORCID 0000-0003-1120-4781
Anne-Kathrin Rausch OsthoffDepartment of Orthopaedics, Rehabilitation and Physical Therapy, Leiden University Medical Center, Albinusdreef 2, P.O. Box 9600, 2300 RC, Leiden, The Netherlands.ORCID 0000-0002-7141-4214
Carsten B JuhlDepartment of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark.ORCID 0000-0001-8456-5364
Karin NiedermannSchool of Health Sciences, Institute of Physiotherapy, Zurich University of Applied Sciences, Winterthur, Switzerland.ORCID 0000-0002-0102-3728
Maaike G J GademanDepartment of Orthopaedics, Rehabilitation and Physical Therapy, Leiden University Medical Center, Albinusdreef 2, P.O. Box 9600, 2300 RC, Leiden, The Netherlands.ORCID 0000-0002-6106-3385
Cornelia H M van den EndeDepartment of Research, Sint Maartenskliniek, Nijmegen, The Netherlands.ORCID 0000-0002-4352-2824
Leiden University Medical Center · NLRadboud University Nijmegen · NLUniversity of Copenhagen · DKZHAW Zurich University of Applied Sciences · CH

Funding

ZonMw 852004019/852004018
6 · The paper itself

Abstract

To describe the quality of reporting and the nature of reported harms in clinical studies on the effectiveness of supervised exercises in patients with rheumatoid arthritis (RA) or axial spondyloarthritis (axSpA). We performed a systematic review, searching eight databases up to February 2023. Randomized controlled trials (RCTs) evaluating supervised exercises in adults with RA or axSpA were considered eligible. Data on harms were extracted according to the CONSORT Harms 2022 Checklist. Among others, it was recorded if harms were prespecified or non-prespecified. Moreover, the nature of reported harms was listed. Forty RCTs were included for RA and 25 for axSpA, of which 29 (73%) and 13 (52%) reported information on harms. In 13 (33%) RCTs in RA and four (16%) in axSpA, the collection of harms outcomes was described in the methods section. Prespecified outcomes were reported by eight (RA) and two (axSpA) RCTs. Non-specified harms outcomes were reported by six (RA) and four (axSpA) RCTs. Prespecified harms outcomes included measures of pain, disease activity, inflammation, and structural joint changes. The nature of non-prespecified harms outcomes varied largely, with pain being most common. A considerable proportion of trials on supervised exercise in RA or axSpA does not or inadequately report harms outcomes. Pain was the most commonly reported prespecified or non-specified harm. For a considerate interpretation of the balance between benefits and harms of supervised exercise in RA or axSpA, use of the CONSORT Harms 2022 Checklist for the design, conduct and reporting of trials is advocated.

Indexed as

Arthritis, RheumatoidAxial SpondyloarthritisAdultHumansPainAxial spondyloarthritisExercise therapyRheumatoid arthritisSafetySystematic review

Identifiers

PMID38030947
OpenAlexW4389154304

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.