ArticleNature microbiology2023
DMSOP-cleaving enzymes are diverse and widely distributed in marine microorganisms.
Article in Nature microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 30 citations in OpenAlex.
- The saltmarsh cordgrass Spartina anglica has novel genomic features that contribute to abiotic stress tolerance.Journal of experimental botany · 2026Article
- Review
- Dimethylsulfoniopropionate metabolism shapes microbial ecology and physiological adaptation during the austral winter in Southern Ocean sea ice and seawater.Nature communications · 2026Article
- Regulation of DMSP organosulfur cycling in ubiquitous Roseobacter marine bacteria.The EMBO journal · 2026Article
- Mining and engineering of ene-reductases from marine sediment metagenome for prochiral ACE inhibitor synthesis.Applied and environmental microbiology · 2026Article
- Predicted shifts in bacterial and algal contributions to DMSP and DMS dynamics during a coastal spring-summer bloom.The ISME journal · 2026Article
- The potential for coupled organic and inorganic sulfur cycles across the terrestrial deep subsurface biosphere.Nature communications · 2025Article
- Cloning and expression of the dimethylsulfoniopropionate lyase geneCurrent research in microbial sciences · 2025Article
- Drivers of seasonal dynamics inCurrent research in microbial sciences · 2025Article
- Elucidation of Spartina dimethylsulfoniopropionate synthesis genes enables engineering of stress tolerant plants.Nature communications · 2024Article
- Cold seep nitrogen fixation and its potential relationship with sulfur cycling.Microbiology spectrum · 2024Article
- Alternative dimethylsulfoniopropionate biosynthesis enzymes in diverse and abundant microorganisms.Nature microbiology · 2024Article
Corrections and comments
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Authors and funding
26 authors at 7 institutions in 4 countries.
Funding
Abstract
Dimethylsulfoxonium propionate (DMSOP) is a recently identified and abundant marine organosulfur compound with roles in oxidative stress protection, global carbon and sulfur cycling and, as shown here, potentially in osmotolerance. Microbial DMSOP cleavage yields dimethyl sulfoxide, a ubiquitous marine metabolite, and acrylate, but the enzymes responsible, and their environmental importance, were unknown. Here we report DMSOP cleavage mechanisms in diverse heterotrophic bacteria, fungi and phototrophic algae not previously known to have this activity, and highlight the unappreciated importance of this process in marine sediment environments. These diverse organisms, including Roseobacter, SAR11 bacteria and Emiliania huxleyi, utilized their dimethylsulfoniopropionate lyase 'Ddd' or 'Alma' enzymes to cleave DMSOP via similar catalytic mechanisms to those for dimethylsulfoniopropionate. Given the annual teragram predictions for DMSOP production and its prevalence in marine sediments, our results highlight that DMSOP cleavage is likely a globally significant process influencing carbon and sulfur fluxes and ecological interactions.
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