ArticleNature microbiology2023
Beet red food colourant can be produced more sustainably with engineered Yarrowia lipolytica.
Article in Nature microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 49 citations in OpenAlex.
- Micro-engineering the future.Nature microbiology · 2026Article
- Advances in Betalain Biosynthesis and Metabolic Engineering for Sustainable Natural Pigment Production.Biotech (Basel (Switzerland)) · 2026Review
- Chassis selection and metabolic fine-tuning enable efficient in planta betalain production.Plant physiology · 2026Article
- Blue Light and Methyl Jasmonate Synergistically Enhance Betalain Accumulation, Antioxidant Enzyme Activity, and Osmotic Adjustment in Sugar Beet (Plants (Basel, Switzerland) · 2026Article
- Intron location and sequence modulate gene expression in Yarrowia lipolytica.Nucleic acids research · 2026Article
- Recombinant production of amaranthin and other betalain variants with yeast cell factories.Synthetic and systems biotechnology · 2025Article
- Sustainable Natural Product Glycosylation: A Critical Evaluation of Biocatalytic and Chemical Approaches.ChemSusChem · 2025Review
- In Vivo DNA Assembly inACS synthetic biology · 2025Article
- Identification of a Red Pigment-Producing Strain ofMicroorganisms · 2025Article
- Pressure-Guided LSTM Modeling for Fermentation Quantification Prediction.Sensors (Basel, Switzerland) · 2025Article
- High-throughput metabolic engineering ofProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Red Beet Process Waste: A Sustainable Glucose Syrup Alternative for Gummy Confectionery.Journal of food science · 2025Article
- Screening of Plant UDP-Glycosyltransferases for Betanin Production in Yeast.Applied biochemistry and biotechnology · 2025Article
- Exploring the Biochemical Profile ofPlants (Basel, Switzerland) · 2025Article
- BAHD acyltransferase from dragon fruit enables production of phyllocactin in engineered yeast.FEMS yeast research · 2025Article
- High-efficiency production of plant-derived pigment dopaxanthin in Escherichia coli by combination engineering.Microbial cell factories · 2024Article
- Biosynthesis and Extraction of Chlorophyll, Carotenoids, Anthocyanins, and Betalaine In Vivo and In Vitro.Current issues in molecular biology · 2024Review
- Amaranth Plants with Various Color Phenotypes Recruit Different Soil Microorganisms in the Rhizosphere.Plants (Basel, Switzerland) · 2024Article
Corrections and comments
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Authors and funding
14 authors at 1 institution in 1 country.
Funding
Abstract
Synthetic food colourants are widely used in the food industry, but consumer concerns about safety and sustainability are driving a need for natural food-colour alternatives. Betanin, which is extracted from red beetroots, is a commonly used natural red food colour. However, the betanin content of beetroot is very low (~0.2% wet weight), which means that the extraction of betanin is incredibly wasteful in terms of land use, processing costs and vegetable waste. Here we developed a sustainability-driven biotechnological process for producing red beet betalains, namely, betanin and its isomer isobetanin, by engineering the oleaginous yeast Yarrowia lipolytica. Metabolic engineering and fermentation optimization enabled production of 1,271 ± 141 mg l
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.