Evidence map›Paper›PMID 38030833›Full record

ArticleDigestive diseases and sciences2024

Vaccine-Preventable Illness Leads to Adverse Outcomes in Liver Transplant Recipients.

Aalam Sohal, Isha Kohli, Hunza Chaudhry, Ishandeep Singh, Kirti Arora, Shivam Kalra, Dino Dukovic, Marina Roytman

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Article in Digestive diseases and sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Aalam SohalDepartment of Hepatology, Liver Institute Northwest, 3216 NE 45Th Pl, Suite 212, Seattle, WA, 98105, USA. asohal@liverinstitutenw.org.ORCID http://orcid.org/0000-0001-8365-7240
Isha KohliGraduate Program in Public Health, Icahn School of Medicine, Mount Sinai, New York, NY, USA.
Hunza ChaudhryDepartment of Internal Medicine, University of California, San Francisco, Fresno, CA, USA.
Ishandeep SinghDayanand Medical College and Hospital, Ludhiana, India.
Kirti AroraDayanand Medical College and Hospital, Ludhiana, India.
Shivam KalraDayanand Medical College and Hospital, Ludhiana, India.
Dino DukovicRoss University of Medical Sciences, Miramar, FL, USA.
Marina RoytmanDepartment of Gastroenterology and Hepatology, University of California, San Francisco, Fresno, CA, USA.
Dayanand Medical College & Hospital · INUniversity of California, San Francisco · USCalifornia Miramar University · USIcahn School of Medicine at Mount Sinai · USLiver Institute Northwest · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLiver transplant recipients (LTR) and patients with chronic liver disease (CLD) are at an increased risk of infections.

aimsThe objective of our study was to assess the incidence, and impact of vaccine preventable illness (VPI) on outcomes in LTR.

methodsNational Inpatient Sample (NIS) 2016-2020 was used to identify adults (age > 18) hospitalized LTR using ICD-10 codes. Data were collected on patient demographics, hospital characteristics, etiology of liver disease, hepatic decompensations and outcomes. Patients were stratified into two groups based on the presence or absence of VPI. Multivariate logistic regression analysis was performed to identify the association between VPI and outcomes.

resultsOut of 170,650 hospitalized LTR, 13.5% of the patients had VPI. The most common VPI was noted to be influenza (10.7%), followed by pneumococcal infection (2.7%). Incidence of mortality (6.9% vs. 1.6%, p < 0.001), ICU admissions (14.3% vs. 3.4%, p < 0.001), and acute kidney injury (AKI) (43.7% vs 37.35%, p < 0.001) was higher in the VPI group.

conclusionMore than 13% of the LT hospitalizations had concomitant VPI. VPI in LTR was associated with worse outcomes. Our data suggests the need to identify factors associated with reduced vaccination rates and identify strategies to improve vaccination rates and responses in these patients.

Indexed as

Liver DiseasesLiver TransplantationVaccinesAdultChronic DiseaseHospitalizationHumansMiddle AgedTransplant RecipientsVaccinationVaccinesInfluenzaLiver transplantNational inpatient samplePneumococcalVaccine preventable

Identifiers

PMID38030833
OpenAlexW4389129947

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.