Evidence map›Paper›PMID 38030726›Full record

ArticleNature2023

FOXP3 recognizes microsatellites and bridges DNA through multimerization.

Wenxiang Zhang, Fangwei Leng, Xi Wang, Ricardo N Ramirez, Jinseok Park, Christophe Benoist, Sun Hur

Open access · hybridAbstract read
In one paragraph

Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. FOXP-stabilization of thebioRxiv : the preprint server for biology · 2026
    Article
  10. Article
  11. Review
  12. Article
  13. A Fkh1/2 binding site array in thebioRxiv : the preprint server for biology · 2025
    Article
  14. Distal enhancers loop to proximal enhancers, not to promoters.Nature reviews. Molecular cell biology · 2025
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Germline whole-exome sequencing revealsJournal for immunotherapy of cancer · 2025
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Wenxiang Zhang *Howard Hughes Medical Institute and Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.ORCID 0000-0001-6528-7629
Fangwei Leng *Howard Hughes Medical Institute and Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.
Xi WangHoward Hughes Medical Institute and Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA.
Ricardo N RamirezDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-1259-5406
Jinseok ParkDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Christophe BenoistDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-1172-6555
Sun HurHoward Hughes Medical Institute and Program in Cellular and Molecular Medicine, Boston Children's Hospital, Boston, MA, USA. Sun.Hur@crystal.harvard.edu.ORCID 0000-0001-5005-5550
Boston Children's Hospital · USHarvard University · USHoward Hughes Medical Institute · US

Funding

Structural and functional analyses of the RIG-I filament in innate immunityR01AI111784 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI HUR, SUN · 2014 to 2023
$4.9M
Specification of Treg cells: learning from FoxP3 deficienciesR01AI165697 · NIAID · HARVARD MEDICAL SCHOOL · PI CHRISTOPHE O. BENOIST · 2022 to 2026
$2.8M
Mechanism of the transcription factor FoxP3 in regulatory T cell developmentR01AI180137 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI Sun Hur · 2024 to 2026
$2.4M
Molecular mechanisms for antiviral signaling and regulation by MDA5 and TRIM65R01AI154653 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI HUR, SUN · 2020 to 2024
$2.2M
NIAID NIH HHS R01 AI111784NIAID NIH HHS R01 AI154653NIAID NIH HHS R01 AI165697NIAID NIH HHS R01 AI180137
6 · The paper itself

Abstract

FOXP3 is a transcription factor that is essential for the development of regulatory T cells, a branch of T cells that suppress excessive inflammation and autoimmunity

Indexed as

DNAForkhead Transcription FactorsMicrosatellite RepeatsBase SequenceConsensus SequenceCryoelectron MicroscopyMutationNucleotide MotifsProtein DomainsProtein MultimerizationT-Lymphocytes, RegulatoryDNAForkhead Transcription Factors

Identifiers

PMID38030726
PMCPMC10719092
OpenAlexW4389132725

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.