Evidence map›Paper›PMID 38030725›Full record

ArticleNature2024

mRNA reading frame maintenance during eukaryotic ribosome translocation.

Nemanja Milicevic, Lasse Jenner, Alexander Myasnikov, Marat Yusupov, Gulnara Yusupova

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Structural basis for emetine inhibition of ribosome translocation inbioRxiv : the preprint server for biology · 2026
    Article
  5. Evolution of a core ribosomal innovation in octopus.bioRxiv : the preprint server for biology · 2026
    Article
  6. Article
  7. Interplay of the ribosome A and CAR sites.NAR genomics and bioinformatics · 2026
    Article
  8. Article
  9. The regulation, function and disease relevance of cytoplasmic tRNAs.Nature reviews. Molecular cell biology · 2026
    Review
  10. Transient ion-mediated interactions regulate subunit rotation in a eukaryotic ribosome.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  11. Article
  12. NNature · 2026
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Nemanja MilicevicInstitute of Genetics and Molecular and Cellular Biology (IGBMC), CNRS UMR7104, INSERM U1258, University of Strasbourg, Strasbourg, France.
Lasse JennerInstitute of Genetics and Molecular and Cellular Biology (IGBMC), CNRS UMR7104, INSERM U1258, University of Strasbourg, Strasbourg, France.ORCID 0000-0003-3917-8853
Alexander MyasnikovDubochet Center for Imaging (DCI), EPFL, Lausanne, Switzerland.ORCID 0000-0003-2607-7121
Marat YusupovInstitute of Genetics and Molecular and Cellular Biology (IGBMC), CNRS UMR7104, INSERM U1258, University of Strasbourg, Strasbourg, France.ORCID 0000-0001-5544-0597
Gulnara YusupovaInstitute of Genetics and Molecular and Cellular Biology (IGBMC), CNRS UMR7104, INSERM U1258, University of Strasbourg, Strasbourg, France. gula@igbmc.fr.ORCID 0000-0002-9119-9136
Centre National de la Recherche Scientifique · FRÉcole Polytechnique Fédérale de Lausanne · CH

Funding

La Fondation pour la Recherche Médicale
6 · The paper itself

Abstract

One of the most critical steps of protein synthesis is coupled translocation of messenger RNA (mRNA) and transfer RNAs (tRNAs) required to advance the mRNA reading frame by one codon. In eukaryotes, translocation is accelerated and its fidelity is maintained by elongation factor 2 (eEF2)

Indexed as

Eukaryotic CellsProtein BiosynthesisReading FramesRibosomesRNA, MessengerAnticodonCodonCryoelectron MicroscopyHistidineIndenesPeptide Elongation Factor 2RNA, TransferRNA, Transfer, Amino AcylAnticodonCodondiphthamideHistidineIndenesPeptide Elongation Factor 2RNA, MessengerRNA, TransferRNA, Transfer, Amino AcylsordarintRNA, peptidyl-

Identifiers

PMID38030725
OpenAlexW4389132741

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.