Evidence map›Paper›PMID 38030611›Full record

ArticleNature communications2023

Internal states as a source of subject-dependent movement variability are represented by large-scale brain networks.

Macauley Smith Breault, Pierre Sacré, Zachary B Fitzgerald, John T Gale, Kathleen E Cullen, Jorge A González-Martínez, Sridevi V Sarma

Abstract read
In one paragraph

Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Macauley Smith BreaultPicower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA. breault@mit.edu.ORCID 0000-0003-1327-5372
Pierre SacréDepartment of Electrical Engineering and Computer Science, School of Engineering, University of Liège, Liège, Belgium.ORCID 0000-0002-7228-1628
Zachary B FitzgeraldDepartment of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
John T GaleDIXI Neurolab, Inc., Oxford, MI, USA.
Kathleen E CullenDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.ORCID 0000-0002-9348-0933
Jorge A González-MartínezDepartment of Neurological Surgery, University of Pittsburgh, Pittsburgh, PA, USA.
Sridevi V SarmaDepartment of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.

Funding

National Science Foundation (NSF) 1137237
6 · The paper itself

Abstract

Humans' ability to adapt and learn relies on reflecting on past performance. These experiences form latent representations called internal states that induce movement variability that improves how we interact with our environment. Our study uncovered temporal dynamics and neural substrates of two states from ten subjects implanted with intracranial depth electrodes while they performed a goal-directed motor task with physical perturbations. We identified two internal states using state-space models: one tracking past errors and the other past perturbations. These states influenced reaction times and speed errors, revealing how subjects strategize from trial history. Using local field potentials from over 100 brain regions, we found large-scale brain networks such as the dorsal attention and default mode network modulate visuospatial attention based on recent performance and environmental feedback. Notably, these networks were more prominent in higher-performing subjects, emphasizing their role in improving motor performance by regulating movement variability through internal states.

Indexed as

BrainBrain MappingHumansLearningMagnetic Resonance ImagingMovement

Identifiers

PMID38030611
PMCPMC10687170

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.