Evidence map›Paper›PMID 38030395›Full record

ArticleNeurology2023

Role of Deployment History on the Association Between Epilepsy and Traumatic Brain Injury in Post-9/11 Era US Veterans.

Amy K Henion, Chen-Pin Wang, Megan Amuan, Hamada H Altalib, Alan R Towne, Sidney R Hinds, Christine Baca, W Curt LaFrance, Anne C Van Cott, Jacob Kean and 4 more

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Amy K HenionFrom the Informatics, Decision-Enhancement and Analytic Sciences Center (IDEAS 2.0) (A.K.H., M.A., E.K., S.P., M.J.V.P.), VA Salt Lake City Health Care System, UT; Division of Epidemiology (A.K.H., A.R., E.K., S.P., M.J.V.P.), University of Utah Health Science Center, Salt Lake City; Division of General and Hospital Medicine and Department of Population Health Sciences (C.-P.W.), University of Texas Health Science Center at San Antonio; and South Texas Veterans Health Care System (C.-P.W.), San Antonio; VA Connecticut Health Care System (H.H.A.), West Haven (H.H.A.); and Department of Neurology & Psychiatry (H.H.A.), Yale School of Medicine, New Haven, CT; Department of Neurology (A.R.T.), Virginia Commonwealth University School of Medicine, Richmond; Department of Neurology/Radiology (S.R.H.), Uniformed Services University of the Health Sciences, Bethesda, MD; and SCS Consulting, LLC (S.R.H.); and NFL Players Association (S.R.H.); and Major League Soccer Players Association (S.R.H.); Epilepsy Center of Excellence (C.B.), Central Virginia Veterans Administration Hospital; and Department of Neurology (C.B.), Virginia Commonwealth University, Richmond; Departments of Psychiatry and Neurology (W.C.L.F.), Brown University; and Department of Psychiatry (W.C.L.F.), Providence VA Medical Center, RI; VA Pittsburgh Healthcare System (A.C.V.C.); and Department of Neurology (A.C.V.C.), University of Pittsburgh School of Medicine, PA; and Division of Health System Innovation and Research (J.K.), Department of Population Health Sciences, University of Utah School of Medicine, Salt Lake City.ORCID 0000-0001-5759-344X
Chen-Pin WangFrom the Informatics, Decision-Enhancement and Analytic Sciences Center (IDEAS 2.0) (A.K.H., M.A., E.K., S.P., M.J.V.P.), VA Salt Lake City Health Care System, UT; Division of Epidemiology (A.K.H., A.R., E.K., S.P., M.J.V.P.), University of Utah Health Science Center, Salt Lake City; Division of General and Hospital Medicine and Department of Population Health Sciences (C.-P.W.), University of Texas Health Science Center at San Antonio; and South Texas Veterans Health Care System (C.-P.W.), San Antonio; VA Connecticut Health Care System (H.H.A.), West Haven (H.H.A.); and Department of Neurology & Psychiatry (H.H.A.), Yale School of Medicine, New Haven, CT; Department of Neurology (A.R.T.), Virginia Commonwealth University School of Medicine, Richmond; Department of Neurology/Radiology (S.R.H.), Uniformed Services University of the Health Sciences, Bethesda, MD; and SCS Consulting, LLC (S.R.H.); and NFL Players Association (S.R.H.); and Major League Soccer Players Association (S.R.H.); Epilepsy Center of Excellence (C.B.), Central Virginia Veterans Administration Hospital; and Department of Neurology (C.B.), Virginia Commonwealth University, Richmond; Departments of Psychiatry and Neurology (W.C.L.F.), Brown University; and Department of Psychiatry (W.C.L.F.), Providence VA Medical Center, RI; VA Pittsburgh Healthcare System (A.C.V.C.); and Department of Neurology (A.C.V.C.), University of Pittsburgh School of Medicine, PA; and Division of Health System Innovation and Research (J.K.), Department of Population Health Sciences, University of Utah School of Medicine, Salt Lake City.ORCID 0000-0002-1670-2838
Megan AmuanFrom the Informatics, Decision-Enhancement and Analytic Sciences Center (IDEAS 2.0) (A.K.H., M.A., E.K., S.P., M.J.V.P.), VA Salt Lake City Health Care System, UT; Division of Epidemiology (A.K.H., A.R., E.K., S.P., M.J.V.P.), University of Utah Health Science Center, Salt Lake City; Division of General and Hospital Medicine and Department of Population Health Sciences (C.-P.W.), University of Texas Health Science Center at San Antonio; and South Texas Veterans Health Care System (C.-P.W.), San Antonio; VA Connecticut Health Care System (H.H.A.), West Haven (H.H.A.); and Department of Neurology & Psychiatry (H.H.A.), Yale School of Medicine, New Haven, CT; Department of Neurology (A.R.T.), Virginia Commonwealth University School of Medicine, Richmond; Department of Neurology/Radiology (S.R.H.), Uniformed Services University of the Health Sciences, Bethesda, MD; and SCS Consulting, LLC (S.R.H.); and NFL Players Association (S.R.H.); and Major League Soccer Players Association (S.R.H.); Epilepsy Center of Excellence (C.B.), Central Virginia Veterans Administration Hospital; and Department of Neurology (C.B.), Virginia Commonwealth University, Richmond; Departments of Psychiatry and Neurology (W.C.L.F.), Brown University; and Department of Psychiatry (W.C.L.F.), Providence VA Medical Center, RI; VA Pittsburgh Healthcare System (A.C.V.C.); and Department of Neurology (A.C.V.C.), University of Pittsburgh School of Medicine, PA; and Division of Health System Innovation and Research (J.K.), Department of Population Health Sciences, University of Utah School of Medicine, Salt Lake City.
Hamada H AltalibFrom the Informatics, Decision-Enhancement and Analytic Sciences Center (IDEAS 2.0) (A.K.H., M.A., E.K., S.P., M.J.V.P.), VA Salt Lake City Health Care System, UT; Division of Epidemiology (A.K.H., A.R., E.K., S.P., M.J.V.P.), University of Utah Health Science Center, Salt Lake City; Division of General and Hospital Medicine and Department of Population Health Sciences (C.-P.W.), University of Texas Health Science Center at San Antonio; and South Texas Veterans Health Care System (C.-P.W.), San Antonio; VA Connecticut Health Care System (H.H.A.), West Haven (H.H.A.); and Department of Neurology & Psychiatry (H.H.A.), Yale School of Medicine, New Haven, CT; Department of Neurology (A.R.T.), Virginia Commonwealth University School of Medicine, Richmond; Department of Neurology/Radiology (S.R.H.), Uniformed Services University of the Health Sciences, Bethesda, MD; and SCS Consulting, LLC (S.R.H.); and NFL Players Association (S.R.H.); and Major League Soccer Players Association (S.R.H.); Epilepsy Center of Excellence (C.B.), Central Virginia Veterans Administration Hospital; and Department of Neurology (C.B.), Virginia Commonwealth University, Richmond; Departments of Psychiatry and Neurology (W.C.L.F.), Brown University; and Department of Psychiatry (W.C.L.F.), Providence VA Medical Center, RI; VA Pittsburgh Healthcare System (A.C.V.C.); and Department of Neurology (A.C.V.C.), University of Pittsburgh School of Medicine, PA; and Division of Health System Innovation and Research (J.K.), Department of Population Health Sciences, University of Utah School of Medicine, Salt Lake City.ORCID 0000-0001-7154-1400
Alan R TowneFrom the Informatics, Decision-Enhancement and Analytic Sciences Center (IDEAS 2.0) (A.K.H., M.A., E.K., S.P., M.J.V.P.), VA Salt Lake City Health Care System, UT; Division of Epidemiology (A.K.H., A.R., E.K., S.P., M.J.V.P.), University of Utah Health Science Center, Salt Lake City; Division of General and Hospital Medicine and Department of Population Health Sciences (C.-P.W.), University of Texas Health Science Center at San Antonio; and South Texas Veterans Health Care System (C.-P.W.), San Antonio; VA Connecticut Health Care System (H.H.A.), West Haven (H.H.A.); and Department of Neurology & Psychiatry (H.H.A.), Yale School of Medicine, New Haven, CT; Department of Neurology (A.R.T.), Virginia Commonwealth University School of Medicine, Richmond; Department of Neurology/Radiology (S.R.H.), Uniformed Services University of the Health Sciences, Bethesda, MD; and SCS Consulting, LLC (S.R.H.); and NFL Players Association (S.R.H.); and Major League Soccer Players Association (S.R.H.); Epilepsy Center of Excellence (C.B.), Central Virginia Veterans Administration Hospital; and Department of Neurology (C.B.), Virginia Commonwealth University, Richmond; Departments of Psychiatry and Neurology (W.C.L.F.), Brown University; and Department of Psychiatry (W.C.L.F.), Providence VA Medical Center, RI; VA Pittsburgh Healthcare System (A.C.V.C.); and Department of Neurology (A.C.V.C.), University of Pittsburgh School of Medicine, PA; and Division of Health System Innovation and Research (J.K.), Department of Population Health Sciences, University of Utah School of Medicine, Salt Lake City.ORCID 0000-0003-4263-7336
Sidney R HindsFrom the Informatics, Decision-Enhancement and Analytic Sciences Center (IDEAS 2.0) (A.K.H., M.A., E.K., S.P., M.J.V.P.), VA Salt Lake City Health Care System, UT; Division of Epidemiology (A.K.H., A.R., E.K., S.P., M.J.V.P.), University of Utah Health Science Center, Salt Lake City; Division of General and Hospital Medicine and Department of Population Health Sciences (C.-P.W.), University of Texas Health Science Center at San Antonio; and South Texas Veterans Health Care System (C.-P.W.), San Antonio; VA Connecticut Health Care System (H.H.A.), West Haven (H.H.A.); and Department of Neurology & Psychiatry (H.H.A.), Yale School of Medicine, New Haven, CT; Department of Neurology (A.R.T.), Virginia Commonwealth University School of Medicine, Richmond; Department of Neurology/Radiology (S.R.H.), Uniformed Services University of the Health Sciences, Bethesda, MD; and SCS Consulting, LLC (S.R.H.); and NFL Players Association (S.R.H.); and Major League Soccer Players Association (S.R.H.); Epilepsy Center of Excellence (C.B.), Central Virginia Veterans Administration Hospital; and Department of Neurology (C.B.), Virginia Commonwealth University, Richmond; Departments of Psychiatry and Neurology (W.C.L.F.), Brown University; and Department of Psychiatry (W.C.L.F.), Providence VA Medical Center, RI; VA Pittsburgh Healthcare System (A.C.V.C.); and Department of Neurology (A.C.V.C.), University of Pittsburgh School of Medicine, PA; and Division of Health System Innovation and Research (J.K.), Department of Population Health Sciences, University of Utah School of Medicine, Salt Lake City.
Christine BacaFrom the Informatics, Decision-Enhancement and Analytic Sciences Center (IDEAS 2.0) (A.K.H., M.A., E.K., S.P., M.J.V.P.), VA Salt Lake City Health Care System, UT; Division of Epidemiology (A.K.H., A.R., E.K., S.P., M.J.V.P.), University of Utah Health Science Center, Salt Lake City; Division of General and Hospital Medicine and Department of Population Health Sciences (C.-P.W.), University of Texas Health Science Center at San Antonio; and South Texas Veterans Health Care System (C.-P.W.), San Antonio; VA Connecticut Health Care System (H.H.A.), West Haven (H.H.A.); and Department of Neurology & Psychiatry (H.H.A.), Yale School of Medicine, New Haven, CT; Department of Neurology (A.R.T.), Virginia Commonwealth University School of Medicine, Richmond; Department of Neurology/Radiology (S.R.H.), Uniformed Services University of the Health Sciences, Bethesda, MD; and SCS Consulting, LLC (S.R.H.); and NFL Players Association (S.R.H.); and Major League Soccer Players Association (S.R.H.); Epilepsy Center of Excellence (C.B.), Central Virginia Veterans Administration Hospital; and Department of Neurology (C.B.), Virginia Commonwealth University, Richmond; Departments of Psychiatry and Neurology (W.C.L.F.), Brown University; and Department of Psychiatry (W.C.L.F.), Providence VA Medical Center, RI; VA Pittsburgh Healthcare System (A.C.V.C.); and Department of Neurology (A.C.V.C.), University of Pittsburgh School of Medicine, PA; and Division of Health System Innovation and Research (J.K.), Department of Population Health Sciences, University of Utah School of Medicine, Salt Lake City.
W Curt LaFranceFrom the Informatics, Decision-Enhancement and Analytic Sciences Center (IDEAS 2.0) (A.K.H., M.A., E.K., S.P., M.J.V.P.), VA Salt Lake City Health Care System, UT; Division of Epidemiology (A.K.H., A.R., E.K., S.P., M.J.V.P.), University of Utah Health Science Center, Salt Lake City; Division of General and Hospital Medicine and Department of Population Health Sciences (C.-P.W.), University of Texas Health Science Center at San Antonio; and South Texas Veterans Health Care System (C.-P.W.), San Antonio; VA Connecticut Health Care System (H.H.A.), West Haven (H.H.A.); and Department of Neurology & Psychiatry (H.H.A.), Yale School of Medicine, New Haven, CT; Department of Neurology (A.R.T.), Virginia Commonwealth University School of Medicine, Richmond; Department of Neurology/Radiology (S.R.H.), Uniformed Services University of the Health Sciences, Bethesda, MD; and SCS Consulting, LLC (S.R.H.); and NFL Players Association (S.R.H.); and Major League Soccer Players Association (S.R.H.); Epilepsy Center of Excellence (C.B.), Central Virginia Veterans Administration Hospital; and Department of Neurology (C.B.), Virginia Commonwealth University, Richmond; Departments of Psychiatry and Neurology (W.C.L.F.), Brown University; and Department of Psychiatry (W.C.L.F.), Providence VA Medical Center, RI; VA Pittsburgh Healthcare System (A.C.V.C.); and Department of Neurology (A.C.V.C.), University of Pittsburgh School of Medicine, PA; and Division of Health System Innovation and Research (J.K.), Department of Population Health Sciences, University of Utah School of Medicine, Salt Lake City.
Anne C Van CottFrom the Informatics, Decision-Enhancement and Analytic Sciences Center (IDEAS 2.0) (A.K.H., M.A., E.K., S.P., M.J.V.P.), VA Salt Lake City Health Care System, UT; Division of Epidemiology (A.K.H., A.R., E.K., S.P., M.J.V.P.), University of Utah Health Science Center, Salt Lake City; Division of General and Hospital Medicine and Department of Population Health Sciences (C.-P.W.), University of Texas Health Science Center at San Antonio; and South Texas Veterans Health Care System (C.-P.W.), San Antonio; VA Connecticut Health Care System (H.H.A.), West Haven (H.H.A.); and Department of Neurology & Psychiatry (H.H.A.), Yale School of Medicine, New Haven, CT; Department of Neurology (A.R.T.), Virginia Commonwealth University School of Medicine, Richmond; Department of Neurology/Radiology (S.R.H.), Uniformed Services University of the Health Sciences, Bethesda, MD; and SCS Consulting, LLC (S.R.H.); and NFL Players Association (S.R.H.); and Major League Soccer Players Association (S.R.H.); Epilepsy Center of Excellence (C.B.), Central Virginia Veterans Administration Hospital; and Department of Neurology (C.B.), Virginia Commonwealth University, Richmond; Departments of Psychiatry and Neurology (W.C.L.F.), Brown University; and Department of Psychiatry (W.C.L.F.), Providence VA Medical Center, RI; VA Pittsburgh Healthcare System (A.C.V.C.); and Department of Neurology (A.C.V.C.), University of Pittsburgh School of Medicine, PA; and Division of Health System Innovation and Research (J.K.), Department of Population Health Sciences, University of Utah School of Medicine, Salt Lake City.
Jacob KeanFrom the Informatics, Decision-Enhancement and Analytic Sciences Center (IDEAS 2.0) (A.K.H., M.A., E.K., S.P., M.J.V.P.), VA Salt Lake City Health Care System, UT; Division of Epidemiology (A.K.H., A.R., E.K., S.P., M.J.V.P.), University of Utah Health Science Center, Salt Lake City; Division of General and Hospital Medicine and Department of Population Health Sciences (C.-P.W.), University of Texas Health Science Center at San Antonio; and South Texas Veterans Health Care System (C.-P.W.), San Antonio; VA Connecticut Health Care System (H.H.A.), West Haven (H.H.A.); and Department of Neurology & Psychiatry (H.H.A.), Yale School of Medicine, New Haven, CT; Department of Neurology (A.R.T.), Virginia Commonwealth University School of Medicine, Richmond; Department of Neurology/Radiology (S.R.H.), Uniformed Services University of the Health Sciences, Bethesda, MD; and SCS Consulting, LLC (S.R.H.); and NFL Players Association (S.R.H.); and Major League Soccer Players Association (S.R.H.); Epilepsy Center of Excellence (C.B.), Central Virginia Veterans Administration Hospital; and Department of Neurology (C.B.), Virginia Commonwealth University, Richmond; Departments of Psychiatry and Neurology (W.C.L.F.), Brown University; and Department of Psychiatry (W.C.L.F.), Providence VA Medical Center, RI; VA Pittsburgh Healthcare System (A.C.V.C.); and Department of Neurology (A.C.V.C.), University of Pittsburgh School of Medicine, PA; and Division of Health System Innovation and Research (J.K.), Department of Population Health Sciences, University of Utah School of Medicine, Salt Lake City.ORCID 0000-0002-8577-0586
Ali RoghaniFrom the Informatics, Decision-Enhancement and Analytic Sciences Center (IDEAS 2.0) (A.K.H., M.A., E.K., S.P., M.J.V.P.), VA Salt Lake City Health Care System, UT; Division of Epidemiology (A.K.H., A.R., E.K., S.P., M.J.V.P.), University of Utah Health Science Center, Salt Lake City; Division of General and Hospital Medicine and Department of Population Health Sciences (C.-P.W.), University of Texas Health Science Center at San Antonio; and South Texas Veterans Health Care System (C.-P.W.), San Antonio; VA Connecticut Health Care System (H.H.A.), West Haven (H.H.A.); and Department of Neurology & Psychiatry (H.H.A.), Yale School of Medicine, New Haven, CT; Department of Neurology (A.R.T.), Virginia Commonwealth University School of Medicine, Richmond; Department of Neurology/Radiology (S.R.H.), Uniformed Services University of the Health Sciences, Bethesda, MD; and SCS Consulting, LLC (S.R.H.); and NFL Players Association (S.R.H.); and Major League Soccer Players Association (S.R.H.); Epilepsy Center of Excellence (C.B.), Central Virginia Veterans Administration Hospital; and Department of Neurology (C.B.), Virginia Commonwealth University, Richmond; Departments of Psychiatry and Neurology (W.C.L.F.), Brown University; and Department of Psychiatry (W.C.L.F.), Providence VA Medical Center, RI; VA Pittsburgh Healthcare System (A.C.V.C.); and Department of Neurology (A.C.V.C.), University of Pittsburgh School of Medicine, PA; and Division of Health System Innovation and Research (J.K.), Department of Population Health Sciences, University of Utah School of Medicine, Salt Lake City.ORCID 0000-0003-4309-592X
Eamonn KennedyFrom the Informatics, Decision-Enhancement and Analytic Sciences Center (IDEAS 2.0) (A.K.H., M.A., E.K., S.P., M.J.V.P.), VA Salt Lake City Health Care System, UT; Division of Epidemiology (A.K.H., A.R., E.K., S.P., M.J.V.P.), University of Utah Health Science Center, Salt Lake City; Division of General and Hospital Medicine and Department of Population Health Sciences (C.-P.W.), University of Texas Health Science Center at San Antonio; and South Texas Veterans Health Care System (C.-P.W.), San Antonio; VA Connecticut Health Care System (H.H.A.), West Haven (H.H.A.); and Department of Neurology & Psychiatry (H.H.A.), Yale School of Medicine, New Haven, CT; Department of Neurology (A.R.T.), Virginia Commonwealth University School of Medicine, Richmond; Department of Neurology/Radiology (S.R.H.), Uniformed Services University of the Health Sciences, Bethesda, MD; and SCS Consulting, LLC (S.R.H.); and NFL Players Association (S.R.H.); and Major League Soccer Players Association (S.R.H.); Epilepsy Center of Excellence (C.B.), Central Virginia Veterans Administration Hospital; and Department of Neurology (C.B.), Virginia Commonwealth University, Richmond; Departments of Psychiatry and Neurology (W.C.L.F.), Brown University; and Department of Psychiatry (W.C.L.F.), Providence VA Medical Center, RI; VA Pittsburgh Healthcare System (A.C.V.C.); and Department of Neurology (A.C.V.C.), University of Pittsburgh School of Medicine, PA; and Division of Health System Innovation and Research (J.K.), Department of Population Health Sciences, University of Utah School of Medicine, Salt Lake City.ORCID 0000-0002-9211-1271
Samin PanahiFrom the Informatics, Decision-Enhancement and Analytic Sciences Center (IDEAS 2.0) (A.K.H., M.A., E.K., S.P., M.J.V.P.), VA Salt Lake City Health Care System, UT; Division of Epidemiology (A.K.H., A.R., E.K., S.P., M.J.V.P.), University of Utah Health Science Center, Salt Lake City; Division of General and Hospital Medicine and Department of Population Health Sciences (C.-P.W.), University of Texas Health Science Center at San Antonio; and South Texas Veterans Health Care System (C.-P.W.), San Antonio; VA Connecticut Health Care System (H.H.A.), West Haven (H.H.A.); and Department of Neurology & Psychiatry (H.H.A.), Yale School of Medicine, New Haven, CT; Department of Neurology (A.R.T.), Virginia Commonwealth University School of Medicine, Richmond; Department of Neurology/Radiology (S.R.H.), Uniformed Services University of the Health Sciences, Bethesda, MD; and SCS Consulting, LLC (S.R.H.); and NFL Players Association (S.R.H.); and Major League Soccer Players Association (S.R.H.); Epilepsy Center of Excellence (C.B.), Central Virginia Veterans Administration Hospital; and Department of Neurology (C.B.), Virginia Commonwealth University, Richmond; Departments of Psychiatry and Neurology (W.C.L.F.), Brown University; and Department of Psychiatry (W.C.L.F.), Providence VA Medical Center, RI; VA Pittsburgh Healthcare System (A.C.V.C.); and Department of Neurology (A.C.V.C.), University of Pittsburgh School of Medicine, PA; and Division of Health System Innovation and Research (J.K.), Department of Population Health Sciences, University of Utah School of Medicine, Salt Lake City.
Mary Jo V PughFrom the Informatics, Decision-Enhancement and Analytic Sciences Center (IDEAS 2.0) (A.K.H., M.A., E.K., S.P., M.J.V.P.), VA Salt Lake City Health Care System, UT; Division of Epidemiology (A.K.H., A.R., E.K., S.P., M.J.V.P.), University of Utah Health Science Center, Salt Lake City; Division of General and Hospital Medicine and Department of Population Health Sciences (C.-P.W.), University of Texas Health Science Center at San Antonio; and South Texas Veterans Health Care System (C.-P.W.), San Antonio; VA Connecticut Health Care System (H.H.A.), West Haven (H.H.A.); and Department of Neurology & Psychiatry (H.H.A.), Yale School of Medicine, New Haven, CT; Department of Neurology (A.R.T.), Virginia Commonwealth University School of Medicine, Richmond; Department of Neurology/Radiology (S.R.H.), Uniformed Services University of the Health Sciences, Bethesda, MD; and SCS Consulting, LLC (S.R.H.); and NFL Players Association (S.R.H.); and Major League Soccer Players Association (S.R.H.); Epilepsy Center of Excellence (C.B.), Central Virginia Veterans Administration Hospital; and Department of Neurology (C.B.), Virginia Commonwealth University, Richmond; Departments of Psychiatry and Neurology (W.C.L.F.), Brown University; and Department of Psychiatry (W.C.L.F.), Providence VA Medical Center, RI; VA Pittsburgh Healthcare System (A.C.V.C.); and Department of Neurology (A.C.V.C.), University of Pittsburgh School of Medicine, PA; and Division of Health System Innovation and Research (J.K.), Department of Population Health Sciences, University of Utah School of Medicine, Salt Lake City.ORCID 0000-0003-4196-7763
The University of Texas Health Science Center at San Antonio · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

BACKGROUND AND

objectivesTraumatic brain injury (TBI) is a well-established epilepsy risk factor and is common among service members. Deployment-related TBI, where combat/blast may be more common, may have different outcomes than nondeployment-related TBI. This work examined associations of all TBI exposures (not just combat), and epilepsy, while adjusting for comorbidities associated with epilepsy, among veterans by deployment status.

methodsThe cohort included post-9/11 veterans with ≥2 years of care in both Veterans Health Administration and Defense Health Agency systems. We identified epilepsy using

resultsThe cohort (n = 938,890) included post-9/11 veterans of whom 27,436 (2.92%) had epilepsy. Most veterans had a history of deployment (70.64%), referred to as "deployed." Epilepsy was more common among veterans who were never deployed ("nondeployed") (3.85% vs 2.54%). Deployed veterans were more likely to have had TBI, compared with the nondeployed veterans (33.94% vs 14.24%), but nondeployed veterans with moderate/severe TBI had higher odds of epilepsy compared with deployed veterans (adjusted odds ratio [aOR] 2.92, 95% CI 2.68-3.17 vs aOR 2.01, 95% CI 1.91-2.11). Penetrating TBI had higher odds of epilepsy among the deployed veterans (aOR 5.33, 95% CI 4.89-5.81), whereas the odds of epilepsy for mild TBI did not significantly differ by deployment status. Although most neurologic conditions were more prevalent among the nondeployed veterans, they were often associated with higher odds of epilepsy in the deployed veterans. DISCUSSION: Deployment history had a significant differential impact on epilepsy predictors. As expected, penetrating TBI had a greater epilepsy impact among deployed veterans perhaps due to combat/blast. Some epilepsy predictors (moderate/severe TBI, multiple sclerosis, and Parkinson disease) had a stronger association in the nondeployed veterans suggesting a potential healthy warrior effect in which such conditions preclude deployment. Other neurologic conditions (e.g., brain tumor, Alzheimer disease/frontotemporal dementia) had a greater epilepsy impact in the deployed veterans. This may be attributable to deployment-related exposures (combat injury, occupational exposures). A better understanding of deployment effects is critical to provide targeted epilepsy prevention in veterans and military service members.

Indexed as

Brain Injuries, TraumaticEpilepsyMilitary PersonnelVeteransComorbidityHumans

Identifiers

PMID38030395
PMCPMC10791059
OpenAlexW4389120531

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