Evidence map›Paper›PMID 38030382›Full record

ArticleGut and liver2024

The Possible Preventative Role of Lactate- and Butyrate-Producing Bacteria in Colorectal Carcinogenesis.

Chin-Hee Song, Nayoung Kim, Ryoung Hee Nam, Soo In Choi, Jae Young Jang, Eun Hye Kim, Jina Choi, Yonghoon Choi, Hyuk Yoon, Sun Min Lee and 1 more

Open access · diamondAbstract read
In one paragraph

Article in Gut and liver, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 21 citations in OpenAlex.

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  18. Optimization ofFrontiers in microbiology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Chin-Hee SongDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.ORCID 0000-0002-3489-5944
Nayoung KimDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.ORCID 0000-0002-9397-0406
Ryoung Hee NamDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.ORCID 0000-0002-6515-4540
Soo In ChoiDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.ORCID 0000-0001-6625-7608
Jae Young JangDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.ORCID 0000-0003-2463-7746
Eun Hye KimDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.ORCID 0009-0007-7915-3972
Jina ChoiDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.ORCID 0000-0002-7297-4256
Yonghoon ChoiDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.ORCID 0000-0002-1331-969X
Hyuk YoonDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.ORCID 0000-0002-2657-0349
Sun Min LeeViral Immunology Laboratory, Institut Pasteur Korea, Seongnam, Korea.ORCID 0000-0002-8438-3365
Yeong-Jae SeokDepartment of Biological Sciences and Institute of Microbiology, Seoul National University, Seoul, Korea.ORCID 0000-0003-0379-3619
Seoul National University Bundang Hospital · KRSeoul National University · KRInstitut Pasteur Korea · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background/Aims: : The gut microbiome has emerged as a key player that mechanistically links various risk factors to colorectal cancer (CRC) etiology. However, the role of the gut microbiome in CRC pathogenesis remains unclear. This study aimed to characterize the gut microbiota in healthy controls (HCs) and patients with colorectal adenoma (AD) and CRC in subgroups based on sex and age. Methods: : Study participants who visited the hospital for surveillance of CRC or gastrointestinal symptoms were prospectively enrolled, and the gut microbiome was analyzed based on fecal samples. Results: : In terms of HC-AD-CRC sequence, commensal bacteria, including lactate-producing ( Conclusions: : The gut microbiome, specifically lactate- and butyrate-producing bacteria, which were found to be abundant in the HC group, may play a role in preventing the progression of CRC. In particular, lactate-producing bacteria, which were found to be less abundant in healthy male controls may contribute to the higher incidence of CRC in males.

Indexed as

ButyratesCarcinogenesisColorectal NeoplasmsFecesGastrointestinal MicrobiomeLactic AcidAdenomaAdultAgedAge FactorsBacteriaCase-Control StudiesFemaleHumansMaleMiddle AgedButyratesLactic AcidAge distributionBiomarkersColorectal neoplasmsGastrointestinal microbiomeSex

Identifiers

PMID38030382
PMCPMC11249946
OpenAlexW4389154298

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.