ArticleRMD open2023
Excess mortality following a first and subsequent osteoporotic fracture: a Danish nationwide register-based cohort study on the mediating effects of comorbidities.
Article in RMD open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 15 citations in OpenAlex.
- Excess mortality up to 7 years after low-trauma hip fracture in the largest urban region in Romania.Archives of osteoporosis · 2026Observational
- Severe infections in giant cell arteritis - incidence over time and relation to large vessel involvement and comorbidities, a population-based study.BMC rheumatology · 2026Article
- Article
- Prevalence and associated risk factors of pneumonia following surgery for geriatric osteoporotic fracture: A nationwide cross-sectional study of China.Scientific reports · 2026Article
- Serious adverse events and mortality among adults with non-surgically treated distal radius fractures- a nationwide population-based cohort study of 184,446 Danish patients.BMC musculoskeletal disorders · 2026Article
- Increased all-cause mortality following distal radius fractures in Danish adults: a register-based matched cohort study.Acta orthopaedica · 2026Article
- Mental disorders and osteoporosis treatment in patients with hip fracture-a Danish population-based cohort study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Article
- Associations of ultra-processed food intake with bone mineral density and fractures in the UK Biobank.The British journal of nutrition · 2026Article
- Perspective: Fragility Fracture Network in the Nordic Orthopaedic Federations countries - the role of orthopaedic surgeons.Acta orthopaedica · 2026Article
- Introducing FREMArchives of osteoporosis · 2025Article
- Increased all-cause mortality following proximal humerus fractures in Danish adults: a register-based matched cohort study of 93,952 fracture cases and 469,760 controls.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Article
- Excess short- and long-term mortality risk following any and hip fractures: a prospective matched cohort study using exposure density sampling.Scientific reports · 2025Article
- Effectiveness and safety of antiresorptive drugs in patients with systemic sclerosis-a retrospective monocentric study.EULAR rheumatology open · 2025Article
- One-year mortality rates of fragility fractures of the pelvis: a systematic review and meta-analysis.EFORT open reviews · 2025Article
- Prediction of imminent osteoporotic fracture risk in Danish postmenopausal women-can the addition of self-reported clinical risk factors improve the prediction of the register-based FREM algorithm?Archives of osteoporosis · 2025Article
- Increased Mortality After Lower Extremity Amputation in a Danish Nationwide Cohort: The Mediating Role of Postoperative Complications.Clinical epidemiology · 2025Article
- Ten-year follow-up of fracture risk in a systematic population-based screening program: the risk-stratified osteoporosis strategy evaluation (ROSE) randomised trial.EClinicalMedicine · 2024Article
- Association of systemic inflammation response index with mortality risk in older patients with hip fracture: a 10-year retrospective cohort study.Frontiers in medicine · 2024Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis study aimed to examine the risk of mortality following incident and subsequent osteoporotic fractures, the effect of different fracture type combinations, and the mediating role of postfracture morbidity in a Danish population.
methodsWe used the National Patient Registry to identify patients ≥60 years with incident major osteoporotic fracture of the hip, vertebrae, wrist or humerus between 2013 and 2018, and controls matched 1:10 on age and sex. Possible mediators were identified using International Classification of Diseases, 10th Revision codes registered in the 6 months following index fracture. HRs were estimated using Cox regression analyses with 95% CIs. The effect of possible mediators was estimated using mediation analyses.
resultsThe study included 106 303 patients and 1 062 988 controls. Mortality following index fracture was highest in the month following hip fractures (HR 10.98 (95% CI 10.23 to 11.79) in women and HR 16.40 (95% CI 15.00 to 17.93) in men). Subsequent hip fractures resulted in the highest HRs for all fracture type combinations. In women, the highest HR was observed in patients with index wrist/subsequent hip fractures (HR 2.43 (95% CI 2.12 to 2.78)). In men, the highest HR was observed in patients with index humerus/subsequent hip fractures (HR 2.69 (95% CI 2.04 to 3.54)). Pneumonia mediated the largest proportion of mortality, but dehydration, urinary tract infection and sepsis were also important factors.
conclusionsThe highest mortality risk was found in the month immediately following both index and subsequent fracture. The combination of index and subsequent fractures at different skeletal sites had a substantial impact on the risk of mortality. Postfracture morbidities were found mediate the association.
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