Evidence map›Paper›PMID 38030223›Full record

ArticleLife science alliance2024

Common analysis of direct RNA sequencinG CUrrently leads to misidentification of m

Kaylee J Watson, Robin E Bromley, Benjamin C Sparklin, Mark T Gasser, Tamanash Bhattacharya, Jarrett F Lebov, Tyonna Tyson, Nan Dai, Laura E Teigen, Karen T Graf and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life science alliance, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Kaylee J WatsonInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID https://orcid.org/0009-0008-2288-5723
Robin E BromleyInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID https://orcid.org/0000-0003-2738-2603
Benjamin C SparklinInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID https://orcid.org/0000-0002-5547-185X
Mark T GasserInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
Tamanash BhattacharyaDepartment of Biology, Indiana University, Bloomington, IN, USA.
Jarrett F LebovInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
Tyonna TysonInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
Nan DaiNew England Biolabs, Ipswich, MA, USA.
Laura E TeigenDepartment of Biology, University of Wisconsin Oshkosh, Oshkosh, WI, USA.
Karen T GrafInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
Jeremy M FosterNew England Biolabs, Ipswich, MA, USA.
Michelle MichalskiDepartment of Biology, University of Wisconsin Oshkosh, Oshkosh, WI, USA.
Vincent M BrunoInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
Amelia Ri LindseyDepartment of Biology, Indiana University, Bloomington, IN, USA.ORCID https://orcid.org/0000-0003-3354-7419
Ivan R CorrêaNew England Biolabs, Ipswich, MA, USA.
Richard W HardyDepartment of Biology, Indiana University, Bloomington, IN, USA.ORCID https://orcid.org/0000-0001-6912-6291
Irene Lg NewtonDepartment of Biology, Indiana University, Bloomington, IN, USA.
Julie C Dunning HotoppInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA jdhotopp@som.umaryland.edu.ORCID https://orcid.org/0000-0003-3862-986X

Funding

Technology CoreU19AI110820 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI RASKO, DAVID A · 2014 to 2023
$36.5M
Systems-Level Research in Microbial PathogenesisT32AI162579 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI NICHOLAS H CARBONETTI, Julie Dunning Hotopp · 2022 to 2026
$1.7M
NIAID NIH HHS T32 AI162579NIAID NIH HHS U19 AI110820
6 · The paper itself

Abstract

RNA modifications, such as methylation, can be detected with Oxford Nanopore Technologies direct RNA sequencing. One commonly used tool for detecting 5-methylcytosine (m

Indexed as

AlgorithmsRNAAnimalsHumansMethylationSequence Analysis, RNARNA

Identifiers

PMID38030223
PMCPMC10687253

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.