Evidence map›Paper›PMID 38030164›Full record

ArticleAnticancer research2023

Potential Roles of Activin in Head and Neck Squamous Cell Carcinoma Progression and Mortality.

Seth Buryska, Ketan Patel, Beverly Wuertz, Patrick M Gaffney, Frank Ondrey

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Anticancer research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Seth BuryskaDepartment of Otolaryngology-Head and Neck Surgery, University of Minnesota, Minneapolis, MN, U.S.A.
Ketan PatelNorth Memorial Health/Blaze Health, Minneapolis, MN, U.S.A.
Beverly WuertzDepartment of Otolaryngology-Head and Neck Surgery, University of Minnesota, Minneapolis, MN, U.S.A.; knier003@umn.edu.
Patrick M GaffneyOklahoma Medical Research Foundation, Oklahoma, OK, U.S.A.
Frank OndreyDepartment of Otolaryngology-Head and Neck Surgery, University of Minnesota, Minneapolis, MN, U.S.A.
University of Minnesota · USNorth Memorial Health Care · USOklahoma Medical Research Foundation · US

Funding

Women's CancerP30CA077598 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Jeffrey S. Miller · 1998 to 2026
$100.4M
Pioglitazone-Metformin Combination Treatment for High Risk Oral PreneoplasiaR01CA254270 · NCI · UNIVERSITY OF MINNESOTA · PI ONDREY, FRANK G. · 2022 to 2025
$1.7M
NCI NIH HHS P30 CA077598NCI NIH HHS R01 CA254270
6 · The paper itself

Abstract

BACKGROUND/

aimActivin, a member of the TGF-β super family of cytokines, is involved in head and neck squamous cell carcinoma (HNSCC). This study examined the constituents of the activin axis in order to further elucidate the role of activin A in HNSCC progression. MATERIALS AND

methodsImmunohistochemistry (IHC), reverse transcription polymerase chain reaction (RT-PCR), MTT, and matrigel invasion assays, in addition to analysis of the tumor cancer genome atlas (TCGA), were employed.

resultsIHC in HNSCC and oral leukoplakia (OPL) lesions demonstrated increased expression of the inhibin subunit βA (INHBA) (p<0.0001), as well as activin receptor type IB (ACVR1B) (p<0.0032) compared to normal mucosa. TCGA analysis revealed increased INHBA expression was associated with lymph node positive tumors (p=0.024), decreased overall survival (p=0.0167), and decreased promoter methylation (p<0.0001). Concomitant up-regulated expression of gene pathways strongly correlated with INHBA expression demonstrated further deleterious effects on survival (p<0.0148).

conclusionActivin may be an important component of early carcinogenesis in OPL and HNSCC with unfavorable effects on clinical end-points such as survival.

Indexed as

ActivinsHead and Neck NeoplasmsGene Expression Regulation, NeoplasticHumansSquamous Cell Carcinoma of Head and NeckActivinsActivinepithelial-to-mesenchymal transitionhead and neck cancersurvivalTGF-β

Identifiers

PMID38030164
PMCPMC11285815
OpenAlexW4389134723

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.