Trial reportESC heart failure2024
Acyl ghrelin increases cardiac output while preserving right ventricular-pulmonary arterial coupling in heart failure.
Trial report in ESC heart failure, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed.
- Post-prandial acyl ghrelin infusion in heart failure patients increases gastric emptying rate.Naunyn-Schmiedeberg's archives of pharmacology · 2026Trial
- Acyl ghrelin increases cardiac output while preserving right ventricular-pulmonary arterial coupling in heart failure.ESC heart failure · 2024Trial
- Ghrelin: An Emerging Therapy for Heart Failure.Clinical endocrinology · 2025Review
- Acyl ghrelin increases cardiac output while preserving right ventricular-pulmonary arterial coupling in heart failure.ESC heart failure · 2025Article
- The role of coronary microcirculation in heart failure with preserved ejection fraction: An unceasing odyssey.Heart failure reviews · 2025Review
- Ghrelin peptide in heart failure: when is showtime?Frontiers in cardiovascular medicine · 2025Article
- Potential mechanisms of acyl-ghrelin in heart failure: Insights into cholinergic modulation.ESC heart failure · 2024Article
- Response to letter about "Potential mechanisms of acyl-ghrelin in heart failure: insights into cholinergic modulation".ESC heart failure · 2024Article
- The protective effect of Ghrelin peptide on doxorubicin hydrochloride induced heart failure in rats.Journal of cardiothoracic surgery · 2024Article
- N-Terminal Pro-Brain Natriuretic Peptide Correlates with Ghrelin and Acyl-Ghrelin in Pre-Dialysis Chronic Kidney Disease.International journal of molecular sciences · 2024Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
aimAcyl ghrelin increases cardiac output (CO) in heart failure with reduced ejection fraction (HFrEF). This could impair the right ventricular-pulmonary arterial coupling (RVPAC), both through an increased venous return and right ventricular afterload. We aim to investigate if acyl ghrelin increases CO with or without worsening the right-sided haemodynamics in HFrEF assessed by RVPAC. METHODS AND
resultsThe Karolinska Acyl ghrelin Trial was a randomized double-blind placebo-controlled trial of acyl ghrelin versus placebo (120-min intravenous infusion) in HFrEF. RVPAC was assessed echocardiographically at baseline and 120 min. ANOVA was used for difference in change between acyl ghrelin versus placebo, adjusted for baseline values. Of the 30 randomized patients, 22 had available RVPAC (acyl ghrelin n = 12, placebo n = 10). Despite a 15% increase in CO in the acyl ghrelin group (from 4.0 (3.5-4.6) to 4.6 (3.9-6.1) L/min, P = 0.003), RVPAC remained unchanged; 5.9 (5.3-7.6) to 6.3 (4.8-7.5) mm·(m/s)
conclusionTreatment with acyl ghrelin increases CO while preserving or even improving RVPAC in HFrEF, possibly due to increased contractility, reduced PVR and/or reduced left sided filling pressures. These potential effects strengthen the role of acyl ghrelin therapy in HFrEF with right ventricular failure.
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Registered trials
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