Evidence map›Paper›PMID 38029839›Full record

ArticleMetabolism: clinical and experimental2024

Rising global burden of cancer attributable to high BMI from 2010 to 2019.

Darren Jun Hao Tan, Cheng Han Ng, Mark Muthiah, Jie Ning Yong, Douglas Chee, Margaret Teng, Zhen Yu Wong, Rebecca Wenling Zeng, Yip Han Chin, Jiong-Wei Wang and 16 more

Abstract read
In one paragraph

Article in Metabolism: clinical and experimental, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed.

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  17. Global Trend of MASH-associated Liver Cancer: A Systematic Analysis From the Global Burden of Disease 2021.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Darren Jun Hao TanYong Loo Lin School of Medicine, National University of Singapore, Singapore.
Cheng Han NgDivision of Gastroenterology and Hepatology, Department of Medicine, National University Health System, Singapore. Electronic address: chenhanng@gmail.com.
Mark MuthiahYong Loo Lin School of Medicine, National University of Singapore, Singapore; Division of Gastroenterology and Hepatology, Department of Medicine, National University Health System, Singapore.
Jie Ning YongYong Loo Lin School of Medicine, National University of Singapore, Singapore.
Douglas CheeDivision of Gastroenterology and Hepatology, Department of Medicine, National University Health System, Singapore.
Margaret TengDivision of Gastroenterology and Hepatology, Department of Medicine, National University Health System, Singapore.
Zhen Yu WongNottingham Hospitals University Trust, Nottingham, England, United Kingdom.
Rebecca Wenling ZengYong Loo Lin School of Medicine, National University of Singapore, Singapore.
Yip Han ChinYong Loo Lin School of Medicine, National University of Singapore, Singapore.
Jiong-Wei WangYong Loo Lin School of Medicine, National University of Singapore, Singapore; Division of Gastroenterology and Hepatology, Department of Medicine, National University Health System, Singapore.
Pojsakorn DanpanichkulDepartment of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Ruveena Bhavani RajaramDepartment of Medicine, Universiti Malaya Medical Centre, Kuala Lumpur, Wilayah Persekutuan, Malaysia.
Ramanuj DasGuptaLaboratory of Precision Oncology and Cancer Evolution, Genome Institute of Singapore, A*STAR, Singapore, Singapore.
Hiroyuki SuzukiDivision of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Kurume, Japan.
Hirokazu TakahashiDivision of Metabolism and Endocrinology, Faculty of Medicine, Saga University, Saga, Japan.
Nobuharu TamakiDepartment of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Tokyo, Japan.
Yock Young DanYong Loo Lin School of Medicine, National University of Singapore, Singapore; Division of Gastroenterology and Hepatology, Department of Medicine, National University Health System, Singapore.
Rashid LuiDepartment of Medicine and Therapeutics, Institute of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, Hong Kong.
Ajay DusejaDepartment of Hepatology, Post Graduate Institute of Medical Education & Research, Chandigarh, India.
Mohammad Shadab SiddiquiDepartment of Internal Medicine, Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University, United States.
Khay Guan YeohYong Loo Lin School of Medicine, National University of Singapore, Singapore; Division of Gastroenterology and Hepatology, Department of Medicine, National University Health System, Singapore.
Arun SanyalDepartment of Internal Medicine, Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University, United States.
Karn WijarnpreechaDivision of Gastroenterology and Hepatology, Department of Medicine, University of Arizona College of Medicine - Phoenix, Phoenix, AZ, USA.
Rohit LoombaNAFLD Research Center, Division of Gastroenterology, University of California at San Diego, La Jolla, CA, United States; Division of Epidemiology, Department of Family Medicine and Public Health, University of California at San Diego, La Jolla, CA, United States.
Christos Socrates MantzorosDepartments of Internal Medicine, Boston VA Healthcare System, and Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States; Faculty of Medicine, Harvard University, Boston, MA, United States.
Daniel Q HuangYong Loo Lin School of Medicine, National University of Singapore, Singapore; Division of Gastroenterology and Hepatology, Department of Medicine, National University Health System, Singapore. Electronic address: daniel_huang@nus.edu.sg.

Funding

UC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3M
Yeast Genetics and Stress Response Genes-BiomedicalP42ES010337 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TUKEY, ROBERT H · 2000 to 2022
$69.8M
Pediatric Trials in Non-Alcoholic Steatohepatitis (NASH)U01DK061734 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ROHIT LOOMBA · 2002 to 2026
$24.4M
Tissue-specific roles of FXR in CVD and NASHP01HL147835 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LOOMBA, ROHIT · 2020 to 2024
$12.2M
San Diego Digestive Diseases Research CenterP30DK120515 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Bernd G. Schnabl · 2019 to 2026
$10.8M
HIV MASLD Clinical Research Network (HCRN)R01DK121378 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI NAGA P CHALASANI, ROHIT LOOMBA · 2020 to 2026
$8.7M
QUS Technology for Diagnosis and Grading of Hepatic Steatosis in NAFLDR01DK106419 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LOOMBA, ROHIT, SIRLIN, CLAUDE B · 2015 to 2019
$3.4M
San Diego Cirrhosis Clinical Research NetworkU01DK130190 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ROHIT LOOMBA · 2021 to 2026
$2.3M
Non-invasive screening of diabetics for advanced fibrosis due to NAFLDR01DK124318 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LOOMBA, ROHIT · 2020 to 2022
$1.7M
NCATS NIH HHS UL1 TR001442NHLBI NIH HHS P01 HL147835NIDDK NIH HHS P30 DK120515NIDDK NIH HHS R01 DK106419NIDDK NIH HHS R01 DK121378NIDDK NIH HHS R01 DK124318NIDDK NIH HHS U01 DK061734NIDDK NIH HHS U01 DK130190NIEHS NIH HHS P42 ES010337
6 · The paper itself

Abstract

backgroundHigh body mass index (BMI) is a major risk factor for cancer development, but its impact on the global burden of cancer remains unclear.

methodsWe estimated global and regional temporal trends in the burden of cancer attributable to high BMI, and the contributions of various cancer types using the framework of the Global Burden of Disease Study.

resultsFrom 2010 to 2019, there was a 35 % increase in deaths and a 34 % increase in disability-adjusted life-years from cancers attributable to high BMI. The age-standardized death rates for cancer attributable to high BMI increased over the study period (annual percentage change [APC] +0.48 %, 95 % CI 0.22 to 0.74 %). The greatest number of deaths from cancer attributable to high BMI occurred in Europe, but the fastest-growing age-standardized death rates and disability-adjusted life-years occurred in Southeast Asia. Liver cancer was the fastest-growing cause of cancer mortality (APC: 1.37 %, 95 % CI 1.25 to 1.49 %) attributable to high BMI.

conclusionThe global burden of cancer-related deaths attributable to high BMI has increased substantially from 2010 to 2019. The greatest increase in age-standardized death rates occurred in Southeast Asia, and liver cancer is the fastest-growing cause of cancer mortality attributable to high BMI. Urgent and sustained measures are required at a global and regional level to reverse these trends and slow the growing burden of cancer attributed to high BMI.

Indexed as

Liver NeoplasmsBody Mass IndexEuropeHumansQuality-Adjusted Life YearsRisk FactorsCancerEpidemiologyEtiologyObesity

Identifiers

PMID38029839
PMCPMC11321712

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.