ArticleAge and ageing2023
Comparing frailty prevalence between countries: validation of the Global Burden of Disease study Frailty Index (GBD-FI) in the survey of health, ageing and retirement in Europe.
Article in Age and ageing, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Inflammation, Metabolic Status and Mental Health as Potential Mediators of the Association Between Socioeconomic Deprivation and Frailty.Prevention science : the official journal of the Society for Prevention Research · 2026Article
- Methionine-supplemented longevity diet increases growth hormone, GLP-1, and FGF21; reduces frailty; and promotes healthspan.Cell metabolism · 2026Article
- Comparing frailty index distribution, mortality and frailty dynamics across multiple countries: applying the 'zero-state' principle to harmonised ageing data.Age and ageing · 2026Article
- Article
- Association of latent class trajectories of frailty with incident symptomatic knee osteoarthritis in Chinese postmenopausal women: a nationwide cohort study from China.Scientific reports · 2026Article
- PhenoAge acceleration, serum tryptophan, and frailty in socially engaged actively aging elderly men.iScience · 2026Article
- Frailty and Socioeconomic Development in the European Region-Associations with Mortality in Middle-Aged and Older Adults.International journal of environmental research and public health · 2026Article
- Care and Health Needs of Older Patients with Frailty in General Practice.Healthcare (Basel, Switzerland) · 2026Article
- Irradiation-induced brain senescence accelerates cardiac aging via systemic mechanisms: insights from transcriptomic profiling.GeroScience · 2026Article
- Cumulative social determinants of health and frailty risk in older adults.BMC geriatrics · 2025Article
- Population-based validation of a frailty index using electronic regional healthcare records for public health use.Scientific reports · 2025Article
- Knowledge, attitude, and practice of frailty management among clinical nurses: a cross-sectional study.BMC geriatrics · 2025Article
- Associated factors of frailty among community-dwelling older adults with multimorbidity from a health ecological perspective: a cross-sectional study.BMC geriatrics · 2025Article
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Authors and funding
6 authors.
Funding
Abstract
backgroundAccurate comparable prevalence proportions are required to better understand the epidemiology of frailty. Estimates in many countries are missing or incomparable. The Global Burden of Disease Frailty Index (GBD-FI) applies the deficit accumulation model to generate frailty scores from items available in the Global Burden of Disease study.
objectiveTo externally validate the GBD-FI.
methodsData were obtained from the Survey of Health Ageing and Retirement in Europe (SHARE). A 20-item modified GBD-FI was compared with established frailty measures: a 70-item frailty index (FI-70), the Clinical Frailty Scale (CFS), Frailty Phenotype (FP) and SHARE-FI. Area under receiver operating characteristic curves (AUC) were fitted to examine diagnostic accuracy for frailty and predictive validity for 2-year mortality.
resultsIn total, 31,624 participants aged ≥50 years from 15 countries were included. Frailty prevalence was 22% using the GBD-FI (ranging from 8% in Switzerland to 41% in Poland). The GBD-FI had good to excellent diagnostic accuracy for frailty, irrespective of approach; the AUC ranged from 0.86 (95% confidence interval: 0.85-0.87) measuring frailty using the CFS to 0.94 (0.93-0.94) with the FI-70. The GBD-FI had similar accuracy for 2-year mortality (AUC 0.71, 0.69-0.74) compared with the CFS (0.73; P = 0.186), FP (0.73; P = 0.392) and SHARE-FI (0.70; P = 0.255) but lower than the FI-70 (0.76; P < 0.001).
conclusionThe GBD-FI demonstrated concurrent and predictive validity, suggesting it is a valid measure of frailty. It has the potential to be an efficient, replicable and consistent approach to comparing frailty between countries and regions across time using GBD data.
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