Evidence map›Paper›PMID 38029233›Full record

ArticleFrontiers in cellular and infection microbiology2023

Survival and prognostic factors of progressive multifocal leukoencephalopathy in people living with HIV in modern ART era.

Rui Jiang, Zichen Song, Li Liu, Xue Mei, Jianjun Sun, Tangkai Qi, Zhenyan Wang, Wei Song, Yang Tang, Junyang Yang and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Rui JiangDepartment of Infection and Immunology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Zichen SongScientifc Research Center, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Li LiuDepartment of Infection and Immunology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Xue MeiDepartment of Liver Intensive Care Unit, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Jianjun SunDepartment of Infection and Immunology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Tangkai QiDepartment of Infection and Immunology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Zhenyan WangDepartment of Infection and Immunology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Wei SongDepartment of Infection and Immunology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Yang TangDepartment of Infection and Immunology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Junyang YangDepartment of Infection and Immunology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Shuibao XuDepartment of Infection and Immunology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Bihe ZhaoDepartment of Infection and Immunology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Yinzhong ShenDepartment of Infection and Immunology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Renfang ZhangDepartment of Infection and Immunology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Jun ChenDepartment of Infection and Immunology, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China.
Shanghai Public Health Clinical Center · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The incidence of progressive multifocal leukoencephalopathy (PML) in people living with HIV (PLWH) is 2%-4%. Currently, there is no effective therapeutic strategy for the treatment of PML in PLWH, resulting in a mortality of up to 50%. This study aimed to identify risk factors of death and prognostic markers in people living with HIV with PML. Methods: A retrospective cohort study of AIDS-related PML individuals was conducted from January 1, 2015, to October 1, 2022, in Shanghai, China. PLWH who were diagnosed with PML for the first time were included. Kaplan-Meier curve and Cox regression were used to analyze the survival and its predictors. Levels of inflammatory markers and immune checkpoint inhibitors in blood and cerebrospinal fluid (CSF) were measured in the prestored samples using bead-based multiplex assay Indolamine 2,3-dioxygenase was determined using ELISA. Results: Twenty of 71 subjects had initiated antiretroviral therapy (ART) before PML onset and no patients discontinued ART during this period. In total, 34 patients (47.9%) had opportunistic infections (OIs), the median CD4+ T cell count was 73.0 (33.0-149.0) cells/μL. The estimated probability of survival at six months was 78% (95% confidential intervals [CIs]:0.63-0.85). OIs, low CD4+ T cell count were associated with lower estimated six-month survival (hazard ratio 8.01, 95% CIs: 1.80-35.00, P=0.006 and 5.01, 95% CIs:1.57-16.03, p=0.007). Indolamine 2,3-dioxygenase activity in CSF of non-survivors group were higher than survivors group (p<0.05). Conclusions: The survival rate of AIDS-related PML in the modern ART era was higher than the survival rate a decade ago. Low CD4+T cell count, OIs, were all associated with death of individuals with AIDS-related PML. The role of IDO in AIDS-related PML warrant further investigation.

Indexed as

Acquired Immunodeficiency SyndromeDioxygenasesHIV InfectionsLeukoencephalopathy, Progressive MultifocalAntiretroviral Therapy, Highly ActiveCD4 Lymphocyte CountChinaHumansPrognosisRetrospective StudiesDioxygenasesHIV/AIDSHIV/AIDS-related neurological disorderspolyoma virusprognostic factorprogressive multifocal leukoencephalopathysurvival rate

Identifiers

PMID38029233
PMCPMC10663249
OpenAlexW4388524302

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.