Integrative transcriptome analysis reveals alternative polyadenylation potentially contributes to GCRV early infection.

Sheng Tan, Jie Zhang, Yonglin Peng, Wenfei Du, Jingxuan Yan, Qin Fang

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Article in Frontiers in microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Sheng Tan *Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai, Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China.

Jie Zhang *State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.

Yonglin Peng *Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai, Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China.

Wenfei DuKey Laboratory of Systems Biomedicine (Ministry of Education), Shanghai, Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China.

Jingxuan YanBio-ID Center, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China.

Qin FangState Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Grass carp reovirus (GCRV), a member of the Methods: In this study we performed transcriptome and DNA methylome analyses with Results: We found that at early infection stage the differentially expressed genes related to defense response and immune response in CIK cells are activated. Although DNA methylation pattern of CIK cells 8 hpi is similar to mock-infected cells, we identified a considerable number of genes that selectively utilize alternative polyadenylation sites. Particularly, we found that biological processes of cytoskeleton organization and regulation of microtubule polymerization are statistically enriched in the genes with altered 3'UTRs. Discussion: Our results suggest that alternative polyadenylation potentially contributes to GCRV early infection.

Indexed as

alternative polyadenylationAquareovirus genusCtenopharyngodon idellusDNA methylationgrass carp reovirus

Identifiers

PMID38029205

DOI10.3389/fmicb.2023.1269164

PMCPMC10656684

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.