Evidence map›Paper›PMID 38029153›Full record

ArticleFrontiers in microbiology2023

Investigation into the mechanism of action of the antimicrobial peptide epilancin 15X.

Chunyu Wu, B Alexis Lower, Ryan Moreira, Darian Dorantes, Tung Le, Constantin Giurgiu, Yanxiang Shi, Wilfred A van der Donk

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Bibacillin 1: A two-component lantibiotic frombioRxiv : the preprint server for biology · 2024
    Article
  2. Article
  3. Towards sustainable antimicrobial therapies forSustainable microbiology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Chunyu WuDepartment of Biochemistry, University of Illinois at Urbana-Champaign, Champaign, IL, United States.
B Alexis LowerDepartment of Chemistry, The Howard Hughes Medical Institute, University of Illinois at Urbana-Champaign, Champaign, IL, United States.
Ryan MoreiraDepartment of Chemistry, The Howard Hughes Medical Institute, University of Illinois at Urbana-Champaign, Champaign, IL, United States.
Darian DorantesDepartment of Biochemistry, University of Illinois at Urbana-Champaign, Champaign, IL, United States.
Tung LeDepartment of Chemistry, The Howard Hughes Medical Institute, University of Illinois at Urbana-Champaign, Champaign, IL, United States.
Constantin GiurgiuDepartment of Chemistry, The Howard Hughes Medical Institute, University of Illinois at Urbana-Champaign, Champaign, IL, United States.
Yanxiang ShiDepartment of Chemistry, The Howard Hughes Medical Institute, University of Illinois at Urbana-Champaign, Champaign, IL, United States.
Wilfred A van der DonkDepartment of Biochemistry, University of Illinois at Urbana-Champaign, Champaign, IL, United States.
Howard Hughes Medical Institute · USUniversity of Illinois Urbana-Champaign · US

Funding

4800 Plus MALDI TOF/TOF AnalyzerS10RR027109 · NCRR · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI VAN DER DONK, WILFRED A. · 2010 to 2010
$395k
NCRR NIH HHS S10 RR027109
6 · The paper itself

Abstract

Addressing the current antibiotic-resistance challenge would be aided by the identification of compounds with novel mechanisms of action. Epilancin 15X, a lantibiotic produced by

Indexed as

antibioticlanthipeptidemembrane-activemicrobiomeRiPPsStaphylococcus

Identifiers

PMID38029153
PMCPMC10652874
OpenAlexW4388298851

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.