Evidence map›Paper›PMID 38028975›Full record

ReviewMethodist DeBakey cardiovascular journal2023

Metabolic Control of Cardiomyocyte Cell Cycle.

Ivan Menendez-Montes, Daniel J Garry, Jianyi Jay Zhang, Hesham A Sadek

Open access · diamondAbstract readReview
In one paragraph

Review in Methodist DeBakey cardiovascular journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 1 country.

Ivan Menendez-MontesUniversity of Texas Southwestern Medical Center, Dallas, Texas, US.ORCID https://orcid.org/0000-0001-5252-9502
Daniel J GarryUniversity of Minnesota, Minneapolis, Minnesota, US.ORCID https://orcid.org/0000-0002-8970-7365
Jianyi Jay ZhangUniversity of Alabama Birmingham, Birmingham, Alabama, US.ORCID https://orcid.org/0000-0002-3955-6554
Hesham A SadekUniversity of Texas Southwestern Medical Center, Dallas, Texas, US.ORCID https://orcid.org/0000-0002-4745-366X
The University of Texas Southwestern Medical Center · USUnited States University · USUniversity of Alabama at Birmingham · USUniversity of Minnesota · US

Funding

Project 3 - Role of Proline Metabolism in Regulation of Mammalian Cardiomyocyte ProliferationP01HL160476 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Jianyi Zhang · 2022 to 2026
$13.1M
T-Cell-Mediated Inflammatory Response in Neonatal Heart RegenerationP01HL160488 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI Hesham Sadek · 2023 to 2026
$10.2M
Supply and Demand: Oxygen and Workload Regulate Cardiomyocyte ProliferationR35HL166563 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI Hesham Sadek · 2023 to 2026
$4.1M
Deciphering the Neonatal Cardiac Regenerative Potential and Regulators in Large AnimalsR01HL149137 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SADEK, HESHAM, ZANGI, LIOR · 2019 to 2022
$2.5M
NHLBI NIH HHS P01 HL160476NHLBI NIH HHS P01 HL160488NHLBI NIH HHS R01 HL149137NHLBI NIH HHS R35 HL166563
6 · The paper itself

Abstract

Current therapies for heart failure aim to prevent the deleterious remodeling that occurs after MI injury, but currently no therapies are available to replace lost cardiomyocytes. Several organisms now being studied are capable of regenerating their myocardium by the proliferation of existing cardiomyocytes. In this review, we summarize the main metabolic pathways of the mammalian heart and how modulation of these metabolic pathways through genetic and pharmacological approaches influences cardiomyocyte proliferation and heart regeneration.

Indexed as

Heart FailureMyocytes, CardiacAnimalsCell CycleCell ProliferationHumansMammalsMyocardiumRegenerationcardiac regenerationcardiomyocyte proliferationglycolysisoxidative phosphorylationreactive oxygen speciesuridine diphosphate N-acetylglucosamine (UDP GlycNAC)

Identifiers

PMID38028975
PMCPMC10655756
OpenAlexW4388739737

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.