Evidence map›Paper›PMID 38028968›Full record

ReviewMethodist DeBakey cardiovascular journal2023

Networks that Govern Cardiomyocyte Proliferation to Facilitate Repair of the Injured Mammalian Heart.

Daniel J Garry, Jianyi Jay Zhang, Thijs A Larson, Hesham A Sadek, Mary G Garry

Open access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Methodist DeBakey cardiovascular journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Daniel J GarryUniversity of Minnesota, Minneapolis, Minnesota, US.ORCID https://orcid.org/0000-0002-8970-7365
Jianyi Jay ZhangUniversity of Alabama at Birmingham, Alabama, US.ORCID https://orcid.org/0000-0002-3955-6554
Thijs A LarsonUniversity of Minnesota, Minneapolis, Minnesota, US.ORCID https://orcid.org/0000-0002-8424-3856
Hesham A SadekUT Southwestern Medical Center at Dallas, Dallas, Texas, US.ORCID https://orcid.org/0000-0002-4745-366X
Mary G GarryNorthStar Genomics, Eagan, Minnesota, US.ORCID https://orcid.org/0000-0002-7958-5560
University of Minnesota · US

Funding

Project 3 - Role of Proline Metabolism in Regulation of Mammalian Cardiomyocyte ProliferationP01HL160476 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Hesham Sadek · 2022 to 2026
$13.1M
Mechanisms that Govern and Promote Cardiovascular RegenerationR01HL148599 · NHLBI · UNIVERSITY OF MINNESOTA · PI GARRY, DANIEL J., GARRY, MARY G · 2019 to 2022
$3.0M
Cardiovascular regeneration and pioneer factorsR01HL168647 · NHLBI · UNIVERSITY OF MINNESOTA · PI Daniel J. Garry · 2023 to 2026
$2.8M
NHLBI NIH HHS P01 HL160476NHLBI NIH HHS R01 HL148599NHLBI NIH HHS R01 HL168647
6 · The paper itself

Abstract

Cardiovascular diseases are the number one cause of death worldwide and in the United States (US). Cardiovascular diseases frequently progress to end-stage heart failure, and curative therapies are extremely limited. Intense interest has focused on deciphering the cascades and networks that govern cardiomyocyte proliferation and regeneration of the injured heart. For example, studies have shown that lower organisms such as the adult newt and adult zebrafish have the capacity to completely regenerate their injured heart with restoration of function. Similarly, the neonatal mouse and pig are also able to completely regenerate injured myocardium due to cardiomyocyte proliferation from preexisting cardiomyocytes. Using these animal models and transcriptome analyses, efforts have focused on the definition of factors and signaling pathways that can reactivate and induce cardiomyocyte proliferation in the adult mammalian injured heart. These studies and discoveries have the potential to define novel therapies to promote cardiomyocyte proliferation and repair of the injured, mammalian heart.

Indexed as

Myocardial InfarctionMyocytes, CardiacAnimalsCell ProliferationMammalsMiceMyocardiumRegenerationSwineZebrafishcardiomyocyte proliferationcell cycle regulatorsHippo signalinghypoxiametabolic factorsmyocardial injurySHH signaling

Identifiers

PMID38028968
PMCPMC10655759
OpenAlexW4388738700

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.