Evidence map›Paper›PMID 38028530›Full record

ArticleInternational journal of ophthalmology2023

Association analysis of BclI with benign lymphoepithelial lesions of the lacrimal gland and glucocorticoids resistance.

Xu-Juan Zhang, Peng-Xiang Zhao, Ming-Shen Ma, Hao Wu, Rui Liu, Hui Wang, Meng-Yu Liu, Fei Xie, Xue-Mei Ma

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of ophthalmology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Xu-Juan ZhangFaculty of Environment and Life, Beijing University of Technology, Beijing 100124, China.
Peng-Xiang ZhaoFaculty of Environment and Life, Beijing University of Technology, Beijing 100124, China.
Ming-Shen MaBeijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
Hao WuFaculty of Environment and Life, Beijing University of Technology, Beijing 100124, China.
Rui LiuBeijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
Hui WangFaculty of Environment and Life, Beijing University of Technology, Beijing 100124, China.
Meng-Yu LiuFaculty of Environment and Life, Beijing University of Technology, Beijing 100124, China.
Fei XieFaculty of Environment and Life, Beijing University of Technology, Beijing 100124, China.
Xue-Mei MaFaculty of Environment and Life, Beijing University of Technology, Beijing 100124, China.
Beijing Tongren Hospital · CNBeijing University of Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo evaluate the relationship between gene polymorphism (BclI, ER22/23EK, N363S) and the occurrence, progression and sensitivity to glucocorticoid of lacrimal gland benign lymphoepithelial lesion (LGBLEL).

methodsClinical peripheral blood samples of 52 LGBLEL patients and 10 normal volunteers were collected for DNA extraction and polymerase chain reaction sequencing to analyze single nucleotide polymorphism (SNP) genotypes. The lacrimal tissues of LGBLEL were surgically removed and made into paraffin sections for subsequent hematoxylin-eosin (HE) and Masson staining analysis. The duration of disease and hormone use of LGBLEL patients from diagnosis to surgery were also analyzed. The Meta-analysis follows PRISMA guidelines to conducted a systematic review of human studies investigating the relationship between the NR3C1 BclI polymorphism and glucocorticoids (GCs) sensitivity.

resultsThere was no association between ER22/23EK or N363S and the occurrence of LGBLEL or GCs sensitivity (

conclusionThe LGBLEL patients who carry the NR3C1 BclI allele C may be more sensitive to GCs and associated with lower fibrosis and slower disease progression. The results may guide the clinical treatment strategy for the LGBLEL patients.

Indexed as

BclIfibrosisglucocorticoids resistancelacrimal gland benign lymphoepithelial lesionsingle nucleotide polymorphisms

Identifiers

PMID38028530
PMCPMC10626361
OpenAlexW4387945158

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.