Evidence map›Paper›PMID 38028432›Full record

ArticleFrontiers in pain research (Lausanne, Switzerland)2023

Transcriptional profiles of non-neuronal and immune cells in mouse trigeminal ganglia.

Jennifer Mecklenburg, Sergey A Shein, Mostafa Malmir, Anahit H Hovhannisyan, Korri Weldon, Yi Zou, Zhao Lai, Yu-Fang Jin, Shivani Ruparel, Alexei V Tumanov and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pain research (Lausanne, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 21 citations in OpenAlex.

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  11. CD4Proceedings of the National Academy of Sciences of the United States of America · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Jennifer MecklenburgDepartment of Endodontics, School of Dentistry, The University of Texas Health Science Center at San Antonio (UTHSCSA), San Antonio, TX, United States.
Sergey A SheinMicrobiology, Immunology & Molecular Genetics Departments, School of Medicine, UTHSCSA, San Antonio, TX, United States.
Mostafa MalmirDepartment of Electrical and Computer Engineering, the University of Texas at San Antonio, San Antonio, TX, United States.
Anahit H HovhannisyanDepartment of Endodontics, School of Dentistry, The University of Texas Health Science Center at San Antonio (UTHSCSA), San Antonio, TX, United States.
Korri WeldonMolecular Medicine, School of Medicine, UTHSCSA, San Antonio, TX, United States.
Yi ZouMolecular Medicine, School of Medicine, UTHSCSA, San Antonio, TX, United States.
Zhao LaiMolecular Medicine, School of Medicine, UTHSCSA, San Antonio, TX, United States.
Yu-Fang JinDepartment of Electrical and Computer Engineering, the University of Texas at San Antonio, San Antonio, TX, United States.
Shivani RuparelDepartment of Endodontics, School of Dentistry, The University of Texas Health Science Center at San Antonio (UTHSCSA), San Antonio, TX, United States.
Alexei V TumanovMicrobiology, Immunology & Molecular Genetics Departments, School of Medicine, UTHSCSA, San Antonio, TX, United States.
Armen N AkopianDepartment of Endodontics, School of Dentistry, The University of Texas Health Science Center at San Antonio (UTHSCSA), San Antonio, TX, United States.
The University of Texas Health Science Center at San Antonio · USThe University of Texas at San Antonio · USChildren's Cancer Center · US

Funding

TISSUE CULTURE---COREP30CA054174 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Lei Zheng · 1991 to 2026
$59.1M
Comprehensive functional phenotyping of trigeminal neurons innervating temporomandibular joint (TMJ) tissues in male, female and aged mice, primates, and humans with and without TMJ disorders (TMJD)..UC2AR082195 · NIAMS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI ARMEN N AKOPIAN, LINDSEY J MACPHERSON · 2022 to 2026
$8.4M
LIGHT and Lymphotoxin targeting for the treatment of chronic orofacial pain conditionsR01DE029187 · NIDCR · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI AKOPIAN, ARMEN N, RUPAREL, SHIVANI B · 2019 to 2021
$3.8M
High Throughput DNA Sequencer: Illumina HiSeq 3000 SequencerS10OD021805 · OD · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI LAI, ZHAO · 2016 to 2016
$600k
FACSAria Fusion cell sorter for Flow Cytometry Shared ResourceS10OD030432 · OD · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI BERTON, MICHAEL T · 2022 to 2022
$596k
NCI NIH HHS P30 CA054174NIAMS NIH HHS UC2 AR082195NIDCR NIH HHS R01 DE029187NIH HHS S10 OD021805NIH HHS S10 OD030432
6 · The paper itself

Abstract

Non-neuronal cells constitute 90%-95% of sensory ganglia. These cells, especially glial and immune cells, play critical roles in the modulation of sensory neurons. This study aimed to identify, profile, and summarize the types of trigeminal ganglion (TG) non-neuronal cells in naïve male mice using published and our own data generated by single-cell RNA sequencing, flow cytometry, and immunohistochemistry. TG has five types of non-neuronal cells, namely, glial, fibroblasts, smooth muscle, endothelial, and immune cells. There is an agreement among publications for glial, fibroblasts, smooth muscle, and endothelial cells. Based on gene profiles, glial cells were classified as myelinated and non-myelinated Schwann cells and satellite glial cells.

Indexed as

gliaimmune cellsmacrophagesneutrophilssingle-cell RNA-seqstromal cellstrigeminal ganglia

Identifiers

PMID38028432
PMCPMC10644122
OpenAlexW4388078005

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.