Evidence map›Paper›PMID 38028428›Full record

ArticleFrontiers in pain research (Lausanne, Switzerland)2023

Virtual reality hypnosis diminishes experimental cold pain and alters autonomic responses.

Claire Terzulli, Chloé Chauvin, Cédric Champagnol Di-Liberti, Sylvain Faisan, Laurent Goffin, Coralie Gianesini, Denis Graff, André Dufour, Edouard Laroche, Eric Salvat and 1 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pain research (Lausanne, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07338292 (VIrtual Reality Induced Pain and anxiEty Relief in Outpatient UROlogical Procedures), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07338292 narecruitingnot on this mapstarted 2025, after this paper: background citation

VIrtual Reality Induced Pain and anxiEty Relief in Outpatient UROlogical Procedures: a Post-marketing Clinical Investigation of REALICA

TypeinterventionalSponsorIstituto Oncologico Veneto IRCCSRan2025 to 2026Enrolled56ConditionsUrologic Diseases, Prostate Biopsy, Flexible Cystoscopy, CircumcisionArmsREALICA, Clinical Practice
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Claire TerzulliCentre National de la Recherche Scientifique, University of Strasbourg, Institut des Neurosciences Cellulaires et Intégratives, Strasbourg, France.
Chloé ChauvinHypnoVR, Strasbourg, France.
Cédric Champagnol Di-LibertiICube Laboratory, University of Strasbourg, Strasbourg, France.
Sylvain FaisanICube Laboratory, University of Strasbourg, Strasbourg, France.
Laurent GoffinICube Laboratory, University of Strasbourg, Strasbourg, France.
Coralie GianesiniHypnoVR, Strasbourg, France.
Denis GraffHypnoVR, Strasbourg, France.
André DufourCentre National de la Recherche Scientifique, University of Strasbourg, Laboratoire de Neurosciences Cognitives et Adaptatives, Strasbourg, France.
Edouard LarocheICube Laboratory, University of Strasbourg, Strasbourg, France.
Eric Salvat *Centre National de la Recherche Scientifique, University of Strasbourg, Institut des Neurosciences Cellulaires et Intégratives, Strasbourg, France.
Pierrick Poisbeau *Centre National de la Recherche Scientifique, University of Strasbourg, Institut des Neurosciences Cellulaires et Intégratives, Strasbourg, France.
Laboratoire des Sciences de l'Ingénieur, de l'Informatique et de l'Imagerie · FRInstitut des Neurosciences Cellulaires et Intégratives · FRLaboratoire de Neurosciences Cognitives et Adaptatives · FRUniversité de Strasbourg · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immersive virtual reality (VR) is a promising tool to reduce pain in clinical setting. Digital scripts displayed by VR disposals can be enriched by several analgesic interventions, which are widely used to reduce pain. One of these techniques is hypnosis induced through the VR script (VRH) which is facilitated by immersive environment and particularly efficient even for low hypnotizable patients. The aim of this study is to assess the efficacy of a VRH script on experimentally induced cold pain perception (intensity and unpleasantness) and physiological expression. 41 healthy volunteers had been recruited in this within-subjects study. They received 9 stimulations of 20 s (3 non-nociceptive cold; 3 low nociceptive cold and 3 highly nociceptive cold) during a VRH session of 20 min (VRH condition) or without VRH (noVRH condition). Physiological monitoring during the cold pain stimulation protocol consisted of recording heart rate, heart rate variability and respiratory frequency. Maximum cold pain intensity perception, measured through the visual analog scale (VAS) on 10, was of 3.66 ± 1.84 (VAS score/10) in noVRH condition and 2.46 ± 1.54 in VRH (Wilcoxon,

Indexed as

analgesiaautonomic changeshypnosispainthermal painvirtual reality

Identifiers

PMID38028428
PMCPMC10651739
OpenAlexW4388225661

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.