Evidence map›Paper›PMID 3802833›Full record

ArticleControlled clinical trials1986

Meta-analysis in clinical trials.

R DerSimonian, N Laird

4 registry-linked trialsAbstract read
PubMed Publisher
In one paragraph

Article in Controlled clinical trials, 1986. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 16,961 papers, 87 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16,961citing papers in PubMed, 87 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03277300 unknown statusnot on this mapstarted 2018, after this paper: background citation

Enteral and Parenteral Feeding in Critically Ill Patients

TypeobservationalSponsorAssiut UniversityRan2018 to 2019Enrolled100ConditionsCritical IllnessArmsdietary supplement
NCT04477941 completednot on this mapstarted 2020, after this paper: background citation

The Association Between Parents' Stress and Feeding Styles and Practices: Systematic Review and Meta-analysis of Observational Studies

TypeobservationalSponsorMathilda VandenheuvelRan2020 to 2022Enrolled1ConditionsParent-Child Relations, Stress, Feeding Behavior
NCT05934058 not yet recruitingnot on this mapstarted 2023, after this paper: background citation

Interaction of Genomic and Dietary Aspects in Gastric Cancer Risk: the Global StoP Project

TypeobservationalSponsorFondazione Policlinico Universitario Agostino Gemelli IRCCSRan2023 to 2027Enrolled383,980ConditionsGastric Cancer
NCT06951308 narecruitingnot on this mapstarted 2025, after this paper: background citation

Efficacy of Carbohydrate Loading in Diabetic Type 2 Patients Undergoing CABG Surgery on CPB

TypeinterventionalSponsorDamascus UniversityRan2025 to 2026Enrolled50ConditionsHeart Surgery, Ischemic Heart DiseaseArmsCarbohydrate loading before surgery
3 · Its place in the literature

Who cites it

16,961 citing papers in PubMed, 87 syntheses or guidelines pooled it.

  1. Ceftriaxone for methicillin-susceptibleAnnals of medicine · 2026
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  8. Aflatoxin MVeterinary medicine and science · 2026
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16,901 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

R DerSimonian
N Laird

Funding

STATISTICAL METHODS FOR LONGITUDINAL STUDIESR01GM029745 · NIGMS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI FITZMAURICE, GARRETT M · 1985 to 2005
$1.1M
BIOSTATISTICIANS FOR CANCER RESEARCHT32CA009424 · NCI · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI GRIZZLE, JAMES E · 1985 to 1985
–
NCI NIH HHS CA09424-03NIGMS NIH HHS GM-29745
6 · The paper itself

Abstract

This paper examines eight published reviews each reporting results from several related trials. Each review pools the results from the relevant trials in order to evaluate the efficacy of a certain treatment for a specified medical condition. These reviews lack consistent assessment of homogeneity of treatment effect before pooling. We discuss a random effects approach to combining evidence from a series of experiments comparing two treatments. This approach incorporates the heterogeneity of effects in the analysis of the overall treatment efficacy. The model can be extended to include relevant covariates which would reduce the heterogeneity and allow for more specific therapeutic recommendations. We suggest a simple noniterative procedure for characterizing the distribution of treatment effects in a series of studies.

Indexed as

Clinical Trials as TopicHumansModels, TheoreticalResearch DesignStatistics as Topic

Identifiers

PMID3802833

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.