Evidence map›Paper›PMID 38028272›Full record

ArticleNeurotrauma reports2023

A Research Protocol to Study the Priming Effects of Breathing Low Oxygen on Enhancing Training-Related Gains in Walking Function for Persons With Spinal Cord Injury: The BO

William M Muter, Linda Mansson, Christopher Tuthill, Shreya Aalla, Stella Barth, Emily Evans, Kelly McKenzie, Sara Prokup, Chen Yang, Milap Sandhu and 8 more

2 registry-linked trialsOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurotrauma reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05563103 narecruitingnot on this map

Breathing Low Oxygen to Enhance Spinal Stimulation Training and Functional Recovery in Persons With Chronic SCI: The BO2ST Trial

TypeinterventionalSponsorSpaulding Rehabilitation HospitalRan2023 to 2026Enrolled60ConditionsSpinal Cord InjuriesArmsDaily acute intermittent hypoxia, Room air (SHAM), Walking + tSTIM, Walking + Sham transcutaneous spinal stimulation (tSHAM)
NCT06521723 narecruitingnot on this mapstarted 2025, after this paper: background citation

Breathing Low Oxygen to Enhance Spinal Stimulation Training and Functional Recovery for Aging Adults With Chronic SCI: The BO2ST-II Trial

TypeinterventionalSponsorSpaulding Rehabilitation HospitalRan2025 to 2028Enrolled60ConditionsSpinal Cord InjuriesArmsDaily acute intermittent hypoxia, Walking + tSTIM
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 1 country.

William M MuterSpaulding Rehabilitation Hospital, Charlestown, Massachusetts, USA.
Linda ManssonSpaulding Rehabilitation Hospital, Charlestown, Massachusetts, USA.
Christopher TuthillSpaulding Rehabilitation Hospital, Charlestown, Massachusetts, USA.
Shreya AallaShirley Ryan AbilityLab, Max Nader Center for Rehabilitation Technologies and Outcomes Research, Chicago, Illinois, USA.
Stella BarthSpaulding Rehabilitation Hospital, Charlestown, Massachusetts, USA.
Emily EvansDepartment of Physical Therapy, Boston University, Boston, Massachusetts, USA.
Kelly McKenzieShirley Ryan AbilityLab, Max Nader Center for Rehabilitation Technologies and Outcomes Research, Chicago, Illinois, USA.
Sara ProkupShirley Ryan AbilityLab, Max Nader Center for Rehabilitation Technologies and Outcomes Research, Chicago, Illinois, USA.
Chen YangShirley Ryan AbilityLab, Max Nader Center for Rehabilitation Technologies and Outcomes Research, Chicago, Illinois, USA.
Milap SandhuShirley Ryan AbilityLab, Max Nader Center for Rehabilitation Technologies and Outcomes Research, Chicago, Illinois, USA.
W Zev RymerShirley Ryan AbilityLab, Max Nader Center for Rehabilitation Technologies and Outcomes Research, Chicago, Illinois, USA.
Victor R EdgertonDepartment of Integrative Biology and Physiology, University of California-Los Angeles, Los Angeles, California, USA.
Parag GadDepartment of Integrative Biology and Physiology, University of California-Los Angeles, Los Angeles, California, USA.
Gordon S MitchellDepartment of Physical Therapy, University of Florida, Gainesville, Florida, USA.
Samuel S WuDepartment of Biostatistics, University of Florida, Gainesville, Florida, USA.
Guogen ShanDepartment of Biostatistics, University of Florida, Gainesville, Florida, USA.
Arun JayaramanShirley Ryan AbilityLab, Max Nader Center for Rehabilitation Technologies and Outcomes Research, Chicago, Illinois, USA.
Randy D TrumbowerSpaulding Rehabilitation Hospital, Charlestown, Massachusetts, USA.
Spaulding Rehabilitation Hospital · USUniversity of Florida · USBoston University · USHarvard University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Brief episodes of low oxygen breathing (therapeutic acute intermittent hypoxia; tAIH) may serve as an effective plasticity-promoting primer to enhance the effects of transcutaneous spinal stimulation-enhanced walking therapy (WALK Trial Registration: ClinicalTrials.gov, NCT05563103.

Indexed as

electrical stimulationhypoxianeurological rehabilitationneuromodulationplasticityspinal cord traumawalking

Identifiers

PMID38028272
PMCPMC10659019
OpenAlexW4388426680

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.