Evidence map›Paper›PMID 38028233›Full record

ArticleCase reports in otolaryngology2023

Diagnostic and Treatment-Related Challenges in Sinonasal Teratocarcinosarcoma: A Report of Three Cases.

W F Julius Scheurleer, Weibel W Braunius, Bernard M Tijink, Luuk M Janssen, Frank A Pameijer, Gerben E Breimer, Ernst J Smid, Remco de Bree, Lot A Devriese, Johannes A Rijken

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PubMed Full text at PMC Publisher
In one paragraph

Article in Case reports in otolaryngology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Teratocarcinosarcoma of the nasal cavity: challenges in the clinico-pathologic perspectives.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025
    Review
  2. Sinonasal teratocarcinosarcoma: a case report of a 41-year-old female.American journal of translational research · 2025
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

W F Julius ScheurleerDepartment of Head and Neck Surgical Oncology, University Medical Center Utrecht, Utrecht, Netherlands.ORCID https://orcid.org/0000-0002-6801-106X
Weibel W BrauniusDepartment of Head and Neck Surgical Oncology, University Medical Center Utrecht, Utrecht, Netherlands.ORCID https://orcid.org/0000-0002-3580-1890
Bernard M TijinkDepartment of Head and Neck Surgical Oncology, University Medical Center Utrecht, Utrecht, Netherlands.ORCID https://orcid.org/0000-0002-4223-2833
Luuk M JanssenDepartment of Head and Neck Surgical Oncology, University Medical Center Utrecht, Utrecht, Netherlands.ORCID https://orcid.org/0000-0002-5166-0901
Frank A PameijerDepartment of Radiology, University Medical Center Utrecht, Utrecht, Netherlands.ORCID https://orcid.org/0000-0002-1624-9332
Gerben E BreimerDepartment of Pathology, University Medical Center Utrecht, Utrecht, Netherlands.ORCID https://orcid.org/0000-0003-0365-3667
Ernst J SmidDepartment of Radiation Oncology, University Medical Center Utrecht, Utrecht, Netherlands.ORCID https://orcid.org/0000-0001-9652-0657
Remco de BreeDepartment of Head and Neck Surgical Oncology, University Medical Center Utrecht, Utrecht, Netherlands.ORCID https://orcid.org/0000-0001-7128-5814
Lot A DevrieseDepartment of Medical Oncology, University Medical Center Utrecht, Utrecht, Netherlands.
Johannes A RijkenDepartment of Head and Neck Surgical Oncology, University Medical Center Utrecht, Utrecht, Netherlands.ORCID https://orcid.org/0000-0002-4579-3249
University Medical Center Utrecht · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Sinonasal teratocarcinosarcoma is a rare, aggressive malignancy located almost exclusively in the nasal cavity, paranasal sinuses, or anterior skull base. Histopathological diagnosis can be challenging due to the heterogeneous composition. Methods: Retrospective analysis of 3 patients with sinonasal teratocarcinosarcoma diagnosed and treated at the University Medical Center Utrecht was conducted. Results: Patients presented with nasal obstruction, epistaxis, headaches, or behavioral changes. All three patients had locally advanced disease, and one had lymph node metastases. Two patients underwent surgery followed by radiotherapy, and one underwent neoadjuvant chemotherapy followed by surgery. The follow-up duration ranged from 3 to 32 months. All three patients died due to progression of their disease. Conclusion: Sinonasal teratocarcinosarcoma is characterized by rapid, aggressive local expansion. The prognosis is poor due to a high risk of metastases and locally recurrent disease. Multimodality treatment consisting of surgery, followed by (chemo)-radiotherapy, is essential for optimizing outcomes. Neoadjuvant therapy offers a promising treatment option.

Identifiers

PMID38028233
PMCPMC10657243
OpenAlexW4388590145

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.