Evidence map›Paper›PMID 38028201›Full record

ArticleMolecular therapy. Nucleic acids2023

Unveiling the role of PUS7-mediated pseudouridylation in host protein interactions specific for the SARS-CoV-2 RNA genome.

Roberto Giambruno, Elsa Zacco, Camilla Ugolini, Andrea Vandelli, Logan Mulroney, Manfredi D'Onghia, Bianca Giuliani, Elena Criscuolo, Matteo Castelli, Nicola Clementi and 7 more

Open access · goldAbstract read
In one paragraph

Article in Molecular therapy. Nucleic acids, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 13 citations in OpenAlex.

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  11. 1-L Transcription of SARS-CoV-2 Spike Protein S1 Subunit.International journal of molecular sciences · 2024
    Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 3 countries.

Roberto GiambrunoCenter for Genomic Science of IIT@SEMM, Fondazione Istituto Italiano di Tecnologia, 20139 Milano, Italy.
Elsa ZaccoCentral RNA and RNA Systems Biology Labs, Centre for Human Technologies (CHT), Istituto Italiano di Tecnologia (IIT), 16152 Genova, Italy.
Camilla UgoliniCenter for Genomic Science of IIT@SEMM, Fondazione Istituto Italiano di Tecnologia, 20139 Milano, Italy.
Andrea VandelliCentral RNA and RNA Systems Biology Labs, Centre for Human Technologies (CHT), Istituto Italiano di Tecnologia (IIT), 16152 Genova, Italy.
Logan MulroneyCenter for Genomic Science of IIT@SEMM, Fondazione Istituto Italiano di Tecnologia, 20139 Milano, Italy.
Manfredi D'OnghiaCenter for Genomic Science of IIT@SEMM, Fondazione Istituto Italiano di Tecnologia, 20139 Milano, Italy.
Bianca GiulianiCenter for Genomic Science of IIT@SEMM, Fondazione Istituto Italiano di Tecnologia, 20139 Milano, Italy.
Elena CriscuoloLaboratory of Microbiology and Virology, Vita-Salute San Raffaele University, 20132 Milan, Italy.
Matteo CastelliLaboratory of Microbiology and Virology, Vita-Salute San Raffaele University, 20132 Milan, Italy.
Nicola ClementiLaboratory of Microbiology and Virology, Vita-Salute San Raffaele University, 20132 Milan, Italy.
Massimo ClementiLaboratory of Microbiology and Virology, Vita-Salute San Raffaele University, 20132 Milan, Italy.
Nicasio ManciniLaboratory of Microbiology and Virology, Vita-Salute San Raffaele University, 20132 Milan, Italy.
Tiziana BonaldiDepartment of Experimental Oncology, European Institute of Oncology IRCCS, 20139 Milano, Italy.
Stefano GustincichCentral RNA and RNA Systems Biology Labs, Centre for Human Technologies (CHT), Istituto Italiano di Tecnologia (IIT), 16152 Genova, Italy.
Tommaso LeonardiCenter for Genomic Science of IIT@SEMM, Fondazione Istituto Italiano di Tecnologia, 20139 Milano, Italy.
Gian Gaetano TartagliaCentral RNA and RNA Systems Biology Labs, Centre for Human Technologies (CHT), Istituto Italiano di Tecnologia (IIT), 16152 Genova, Italy.
Francesco NicassioCenter for Genomic Science of IIT@SEMM, Fondazione Istituto Italiano di Tecnologia, 20139 Milano, Italy.
Italian Institute of Technology · ITVita-Salute San Raffaele University · ITUniversity of Milan · ITEuropean Bioinformatics Institute · GBInstitució Catalana de Recerca i Estudis Avançats · ESUniversitat Autònoma de Barcelona · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a positive single-stranded RNA virus, engages in complex interactions with host cell proteins throughout its life cycle. While these interactions enable the host to recognize and inhibit viral replication, they also facilitate essential viral processes such as transcription, translation, and replication. Many aspects of these virus-host interactions remain poorly understood. Here, we employed the

Indexed as

catRAPIDMT: RNA/DNA editingnanocomporenanopore direct-RNA sequencingprotein-RNA interactionsproximity biotinylationpseudouridinePUS7RNA-binding proteinsSARS-CoV-2

Identifiers

PMID38028201
PMCPMC10630655
OpenAlexW4387936402

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.