ArticleClinical case reports2023
Uremic encephalopathy manifesting with a unique MRI finding (the lentiform fork sign) in an adult male: A case report.
Article in Clinical case reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 5 citations in OpenAlex.
- A hemodialysis patient with recurrent Wernicke encephalopathy showed reversible lentiform fork sign: A case report.Medicine · 2026Article
- Case Report: Uremic encephalopathy in acute kidney injury caused by abdominal sepsis.Frontiers in radiology · 2026Article
- Metformin-Associated Encephalopathy as a Rare but Serious Adverse Effect: A Case Report.Cureus · 2026Article
- Article
- Uremic encephalopathy manifesting with a unique MRI finding (the lentiform fork sign) in an adult male: A case report.Clinical case reports · 2023Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A novel radiologic sign in patients with renal failure and uremic encephalopathy (UE) with metabolic acidosis has recently been identified as the lentiform fork sign. On magnetic resonance imaging (MRI), the "lentiform fork sign" has been described as bilateral symmetrical hyperintensities in the basal ganglia encircled by a hyperintese rim delineating the lentiform nucleus. Changes in uremic solute retention, aberrant blood-brain barrier transport, disordered vascular reactivity, altered electrolyte and acid-base balance, and altered hormone metabolism are the most likely causes of the condition. A 56-year-old male with end-stage renal disease was brought to the emergency room for a progressive change in mental status and involuntary arm movements over the previous 5 days, which were accompanied by mild dyspnea. A brain MRI was performed, and it revealed hyperintensity on T2/FLAIR in the white matter surrounding the basal ganglia. the patient was treated with dialysis and improved greatly. Intensified hemodialysis and glycemic control are the cornerstones of treating diabetic uremic syndrome (DUS) with likely reversible clinical symptoms and remission of imaging abnormalities.
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