Evidence map›Paper›PMID 38028043›Full record

ArticleClinical case reports2023

Transient EDTA-dependent pseudothrombocytopenia and ulcerative colitis recurrence during chemotherapy: A case of misleading platelet count results attributable to a laboratory artifact.

Ayako Watanabe, Hirokazu Toshima, Misa Saeki, Takuya Nagata, Tatsuo Koyanagi, Masumi Minamizawa, Yuka Kashiwabara, Koji Kobayashi, Ken Shimada, Kenji Momo

Open access · goldAbstract readCase Reports
In one paragraph

Article in Clinical case reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Ayako WatanabeDepartment of Pharmacy Showa University Koto Toyosu Hospital Tokyo Japan.ORCID https://orcid.org/0000-0003-3844-1891
Hirokazu ToshimaDepartment of Oncology Showa University Koto Toyosu Hospital Tokyo Japan.
Misa SaekiDepartment of Pharmacy Showa University Koto Toyosu Hospital Tokyo Japan.
Takuya NagataDepartment of Pharmacy Showa University Koto Toyosu Hospital Tokyo Japan.
Tatsuo KoyanagiDepartment of Clinical Genomics, BML, Inc Tokyo Japan.
Masumi MinamizawaDepartment of Clinical Genomics, BML, Inc Tokyo Japan.
Yuka KashiwabaraDepartment of Pharmacy Showa University Koto Toyosu Hospital Tokyo Japan.
Koji KobayashiDepartment of Oncology Showa University Koto Toyosu Hospital Tokyo Japan.
Ken ShimadaDepartment of Oncology Showa University Koto Toyosu Hospital Tokyo Japan.
Kenji MomoDepartment of Hospital Pharmaceutics School of Pharmacy Showa University Tokyo Japan.ORCID https://orcid.org/0000-0001-9856-0097
Showa University · JPID Genomics (United States) · USShowa University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Key Clinical Message: EDTA-dependent pseudothrombocytopenia as well as myelosuppression should be suspected when thrombocytopenia occurs in patients with autoimmune disease during chemotherapy. Abstract: A patient with pancreatic cancer and ulcerative colitis developed transient ethylenediaminetetraacetic acid (EDTA)-dependent pseudothrombocytopenia with exacerbation of ulcerative colitis during chemotherapy. Unfortunately, pseudothrombocytopenia could not be immediately detected because thrombocytopenia was masked by a reasonable time course of adverse events associated with chemotherapy and ulcerative colitis recurrence. When thrombocytopenia occurs during chemotherapy, especially in patients with autoimmune diseases, EDTA-dependent pseudothrombocytopenia and bone marrow suppression caused by anti-cancer agents should be suspected.

Indexed as

autoimmune diseasedelayed treatmentlaboratory artifactmisleading diagnosistransient EDTA‐dependent pseudothrombocytopenia

Identifiers

PMID38028043
PMCPMC10663534
OpenAlexW4388904175

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.