Evidence map›Paper›PMID 38027817›Full record

ArticleHeliyon2023

ACE2/ACE imbalance mediates bisphenol A-induced lung injury in Wistar rats: Results from captopril versus losartan histo-biochemical study.

Ahmed A Morsi, Ezat A Mersal, Ahmed M Abdelmoneim, Eman Mohamed Faruk, Mohamed M Sofii, Nehad Ahmed Sadek, Khalid Elfaki Ibrahim, Hatem J Aljanfawe, Iman Elmadhoun, Wejdan Mubarak and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 3 countries.

Ahmed A MorsiDepartment of Histology and Cell Biology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
Ezat A MersalBiochemistry Department, Faculty of Science, Assiut University, Assiut, Egypt.
Ahmed M AbdelmoneimPhysiology Department, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
Eman Mohamed FarukAnatomy Department, College of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia.
Mohamed M SofiiDepartment of Anatomy and Embryology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
Nehad Ahmed SadekDepartment of Histology and Cell Biology, Faculty of Medicine, Fayoum University, Fayoum, Egypt.
Khalid Elfaki IbrahimDepartment of Zoology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.
Hatem J AljanfaweVision Colleges, Riyadh, Saudi Arabia.
Iman ElmadhounVision Colleges, Riyadh, Saudi Arabia.
Wejdan MubarakVision Colleges, Riyadh, Saudi Arabia.
Mashael Malik MahmoudVision Colleges, Riyadh, Saudi Arabia.
Mohamed S SalimMedical Laboratory Technology Department, Higher Technological Institute of Applied Health Sciences, Beni-Suef, Egypt.
Fayoum University · EGHigher Technological Institute · EGKing Saud University · SASion College · GBUmm al-Qura University · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bisphenol-A (BPA) is a synthetic chemical compound broadly used in the plastic and epoxy resin industries with a considerable potential for food contamination. Literary reports have suggested that the altered renin-angiotensin system (RAS) is a mechanism for lung injury and inflammation caused by variable agents. The current study sought to investigate the contribution of RAS to BPA-induced lung damage. Moreover, the study assessed whether angiotensin II and/or bradykinin pathways were involved. For this aim, the angiotensin-converting enzyme (ACE) inhibitor captopril (Cap), either alone or combined with bradykinin receptor antagonist icatibant (Icat), was attempted versus the angiotensin receptor blocker losartan (Los). An eight-week study was conducted on forty Wistar male albino rats randomly divided into five equal groups: control, BPA, BPA/Cap, BPA/Los, and BPA/Cap/Icat groups. Captopril (100 mg/mL) and losartan (200 mg/mL) were given orally in drinking water, but icatibant (Icat) was injected subcutaneously (250 μg/kg) during the last two weeks of captopril treatment. Biochemical analysis of bronchoalveolar lavage fluid (BALF) and lung tissues, polymerase chain reaction (PCR) assay for

Indexed as

Altered renin-angiotensin systemBPA lung injuryInflammation/apoptosisRat immunohistochemistry

Identifiers

PMID38027817
PMCPMC10661530
OpenAlexW4388343063

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.