ArticleBMJ medicine2023
Effect of national guidance on survival for babies born at 22 weeks' gestation in England and Wales: population based cohort study.
Article in BMJ medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT07616778 (Clinical Management and Short-Term Outcomes of Neonates Born at 22 Weeks in the UK), which is not on this map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical Management and Short-Term Outcomes of Neonates Born at 22 Weeks in the UK (The 22 Week Study)
Who cites it
25 citing papers in PubMed.
- Article
- Survival and pre-discharge outcomes of extremely preterm neonates: a single- center prospective cohort study from the United Arab Emirates.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- At the edge of viability: neonatologists' moral experience under uncertainty in Türkiye.BMC medical ethics · 2026Article
- Variations in survival outcomes of infants born at 22-23 weeks' gestation by neonatal intensive care quality level in Korea.Scientific reports · 2026Article
- Harnessing routinely collected data for the evaluation of early years interventions: insights from a scoping review of evaluation studies.International journal of population data science · 2026Article
- Management of locally advanced lynch syndrome rectal cancer during pregnancy with neoadjuvant immunochemotherapy: a case report.Frontiers in oncology · 2026Article
- Chronic respiratory morbidity and wheeze after preterm birth: a narrative review.Frontiers in pediatrics · 2026Review
- Risk factors of early mortality within 72 hours of birth in neonates born at 22 23 weeks' gestation.BMC pediatrics · 2025Article
- Developing and validating an explainable digital mortality prediction tool for extremely preterm infants.PLOS digital health · 2025Article
- Outcomes of Infants Born at 21 Weeks' Gestational Age.JAMA network open · 2025Article
- Outcomes of Preterm Infants Born at 22 to 23 Weeks' Gestation in 11 International Neonatal Networks.JAMA pediatrics · 2025Article
- Research priorities for the most premature babies born <25 weeks' gestation: results of an international priority setting partnership.Archives of disease in childhood. Fetal and neonatal edition · 2025Article
- Mortality risk factors in actively resuscitated 22-week preterm infants: a case-control study focusing on NEC and maternal hospitalization.BMC pediatrics · 2025Article
- Transition from neonatal to paediatric intensive care of very preterm-born children: a cohort study of children born between 2013 and 2018 in England and Wales.Archives of disease in childhood. Fetal and neonatal edition · 2025Article
- The impact of standardization of care for neonates born at 22-23 weeks gestation.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Intraventricular Hemorrhage and Survival, Multimorbidity, and Neurodevelopment.JAMA network open · 2025Article
- Supporting continuing bonds for parents with infants with uncertain futures on neonatal units in the United Kingdom: co-designing a culturally sensitive music therapy intervention.Frontiers in psychiatry · 2025Article
- A network analysis of timing and conditions present at time of death for periviable infants (22+0-23+6 weeks) admitted to neonatal intensive care after receiving survival-focused care at birth.Frontiers in pediatrics · 2025Article
- Need for national guidance regarding proactive care of infants born at 22-23 weeks' gestation.Clinical and experimental pediatrics · 2025Article
- Brain 3T magnetic resonance imaging in neonates: features and incidental findings from a research cohort enriched for preterm birth.Archives of disease in childhood. Fetal and neonatal edition · 2024Article
Corrections and comments
- Erratum issuedCorrection:2023
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: To explore the effect of changes in national clinical recommendations in 2019 that extended provision of survival focused care to babies born at 22 weeks' gestation in England and Wales. Design: Population based cohort study. Setting: England and Wales, comprising routine data for births and hospital records. Participants: Babies alive at the onset of care in labour at 22 weeks+0 days to 22 weeks+6 days and at 23 weeks+0 days to 24 weeks+6 days for comparison purposes between 1 January 2018 and 31 December 2021. Main outcome measures: Percentage of babies given survival focused care (active respiratory support after birth), admitted to neonatal care, and surviving to discharge in 2018-19 and 2020-21. Results: For the 1001 babies alive at the onset of labour at 22 weeks' gestation, a threefold increase was noted in: survival focused care provision from 11.3% to 38.4% (risk ratio 3.41 (95% confidence interval 2.61 to 4.45)); admissions to neonatal units from 7.4% to 28.1% (3.77 (2.70 to 5.27)), and survival to discharge from neonatal care from 2.5% to 8.2% (3.29 (1.78 to 6.09)). More babies of lower birth weight and early gestational age received survival focused care in 2020-21 than 2018-19 (46% to 64% at <500g weight; 19% to 31% at 22 weeks+0 days to 22 weeks+3 days). Conclusions: A change in national guidance to recommend a risk based approach was associated with a threefold increase in 22 weeks' gestation babies receiving survival focused care. The number of babies being admitted to neonatal units and those surviving to discharge increased.
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