ArticlePatient preference and adherence2023
Is Non-Adherence Associated with Adverse Outcomes in Kidney Transplant Recipients? The Role of Non-Adherence as a Risk and Predictor Factor for Graft Loss and Death.
Article in Patient preference and adherence, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Psychological factors associated with medication non-adherence after kidney transplant: a systematic review.BMC psychology · 2026Pooled it
- A Qualitative Study of Patients, Caregivers, and Providers on Barriers to Kidney Retransplantation following Graft Loss.Clinical journal of the American Society of Nephrology : CJASN · 2026Article
- Substance Use Patterns in Pediatric Solid Organ Transplant Candidates: Impact After Transplant.Pediatric transplantation · 2026Article
- Evaluation of medication adherence over a decade following kidney transplantation: integration of biological and self-reported data.BMC nephrology · 2026Article
- A nurse-led program to improve immunosuppressant medication adherence in adult kidney transplant recipients: a randomized clinical trial.BMC nursing · 2026Article
- The relationship between alexithymia, emotion regulation, psychological resilience, and self-management behaviors in kidney transplant recipients: a multicenter structural equation modeling study.Frontiers in psychiatry · 2026Article
- Exploring Early Symptom Experiences and Self-Management Strategies Among Postoperative Kidney Transplant Patients on Symptom Management Theory: A Qualitative Study.Patient preference and adherence · 2025Article
- Population pharmacokinetic modeling of missed mycophenolate mofetil doses: Impact on exposure and exploration of mitigation strategies.PloS one · 2025Article
- The Predictive Power of the Transplant Evaluation Rating Scale (TERS) for Psychosocial Outcomes in Living-Donor Kidney Transplant Recipients: A Two-Year Prospective Study.Journal of clinical medicine · 2024Article
- Transition of care from pediatric to adult nephrology post-renal transplant: a review.Translational pediatrics · 2024Review
- Self-Management of Kidney Transplant Recipients Research: A Comprehensive Bibliometric Analysis.Journal of multidisciplinary healthcare · 2024Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Non-adherence in kidney transplants is diversely defined. Immunosuppression non-adherence (INA) is the most used definition and has been associated with graft loss and acute rejection. But INA assesses only one fraction of adherence. Therefore, we analyzed the association of a holistic non-adherence definition with transplant outcomes and compared its prediction performance with other definitions. Methods: We retrospectively included 739 kidney recipients between 2019 and 2021. We evaluated holistic non-adherence (HNA), suboptimal-immunosuppressor levels (SIL), appointment non-adherence (ANA), procedure non-adherence (PNA) and INA. The main outcomes were graft loss, graft rejection, and mortality. A backward logistic regression was performed estimating adjusted and un-adjusted odds ratio (OR) for each outcome. Finally, we compared the non-adherence definitions' prediction for the main outcomes using the area under the curve. Results: HNA was present in 28.7% of patients. Non-adherent patients had an adjusted OR of 2.66 (1.37-5.15) for mortality, 6.44 for graft loss (2.71-16.6), and 2.28 (1.15-4.47) for graft rejection. INA and PNA presented a moderate discrimination for graft loss and HNA and ANA mild-to-moderate discrimination for graft loss and death. Conclusion: Holistic non-adherence was associated with worst outcomes in kidney recipients and had a significant prediction performance for graft loss and mortality.
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