Evidence map›Paper›PMID 38026845›Full record

ArticleFrontiers in bioengineering and biotechnology2023

Multifunctional electrospun nanofibrous scaffold enriched with alendronate and hydroxyapatite for balancing osteogenic and osteoclast activity to promote bone regeneration.

Shabnam Anjum, Dilip Kumar Arya, Mohammad Saeed, Daoud Ali, Mohammad Saud Athar, Wang Yulin, Saud Alarifi, Xixi Wu, P S Rajinikanth, Qiang Ao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 33 citations in OpenAlex.

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  9. Beyond resorption: osteoclasts as drivers of bone formation.Cell regeneration (London, England) · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 3 countries.

Shabnam AnjumDepartment of Tissue Engineering, School of Intelligent Medicine, China Medical University, Shenyang, Liaoning, China.
Dilip Kumar AryaDepartment of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Lucknow, India.
Mohammad SaeedDepartment of Pharmacology, Dr. A.P.J. Abdul Kalam Technical University, Lucknow, India.
Daoud AliDepartment of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia.
Mohammad Saud AtharDepartment of Chemistry, Aligarh Muslim University, Aligarh, India.
Wang YulinNMPA Key Laboratory for Quality Research and Control of Tissue Regenerative Biomaterial, Institute of Regulatory Science for Medical Device, National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, Sichuan, China.
Saud AlarifiDepartment of Zoology, College of Science, King Saud University, Riyadh, Saudi Arabia.
Xixi WuNMPA Key Laboratory for Quality Research and Control of Tissue Regenerative Biomaterial, Institute of Regulatory Science for Medical Device, National Engineering Research Center for Biomaterials, Sichuan University, Chengdu, Sichuan, China.
P S RajinikanthDepartment of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, Lucknow, India.
Qiang AoDepartment of Tissue Engineering, School of Intelligent Medicine, China Medical University, Shenyang, Liaoning, China.
Babasaheb Bhimrao Ambedkar University · INChina Medical University · CNKing Saud University · SASichuan University · CNAligarh Muslim University · INDr. A.P.J. Abdul Kalam Technical University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Electrospun composite nanofiber scaffolds are well known for their bone and tissue regeneration applications. This research is focused on the development of PVP and PVA nanofiber composite scaffolds enriched with hydroxyapatite (HA) nanoparticles and alendronate (ALN) using the electrospinning technique. The developed nanofiber scaffolds were investigated for their physicochemical as well as bone regeneration potential. The results obtained from particle size, zeta potential, SEM and EDX analysis of HA nanoparticles confirmed their successful fabrication. Further, SEM analysis verified nanofiber's diameters within 200-250 nm, while EDX analysis confirmed the successful incorporation of HA and ALN into the scaffolds. XRD and TGA analysis revealed the amorphous and thermally stable nature of the nanofiber composite scaffolds. Contact angle, FTIR analysis, Swelling and biodegradability studies revealed the hydrophilicity, chemical compatibility, suitable water uptake capacity and increased

Indexed as

alendronatebone regenerationelectrospinninghydroxyapatite nanoparticlenanofibrous scaffold

Identifiers

PMID38026845
PMCPMC10665524
OpenAlexW4388589502

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.