ArticleACS earth & space chemistry2023
A Robust Capillary Electrophoresis with Laser-Induced Fluorescence Detection (CE-LIF) Method for Quantitative Compositional Analysis of Trace Amino Acids in Hypersaline Samples.
Article in ACS earth & space chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Development of a Low-Cost and Easy-Assembly Capillary Electrophoresis System for Separation of DNA.Bioengineering (Basel, Switzerland) · 2025Article
- Biosignature Molecules Accumulate and Persist in Evaporitic Brines: Implications for Planetary Exploration.Astrobiology · 2024Article
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Authors and funding
5 authors.
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Abstract
The search for life in our solar system can be enabled by the characterization of extreme environments representing conditions expected on other planets within our solar system. Molecular abundances observed in these environments help establish instrument design requirements, including limits of detection and pH/salt tolerance, and may be used for validation of proposed planetary science instrumentation. Here, we optimize capillary electrophoresis with laser-induced fluorescence detection (CE-LIF) separations for low limit of detection quantitative compositional analysis of amino acids in hypersaline samples using carboxyfluorescein succinimidyl ester (CFSE) as the amine-reactive fluorescent probe. Two methods were optimized for identification and quantification of proteinogenic amino acids, those with and those without acidic side chains, with limits of detection as low as 250 pM, improving on previous CFSE-amino acid CE-LIF methods by an order of magnitude. The resilience of the method to samples with high concentrations of Mg
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