Evidence map›Paper›PMID 38026667›Full record

ArticleFrontiers in veterinary science2023

Therapeutic effect of aged garlic extract on gingivitis in dogs.

Kaori Takahashi, Hiroshi Nango, Mitsuyasu Ushijima, Miyuki Takashima, Masato Nakamoto, Toshiaki Matsutomo, Hiroshi Jikihara, Nanami Arakawa, Shinichiro Maki, Akira Yabuki and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in veterinary science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. The Effect of the Type and Concentration of Garlic (Animals : an open access journal from MDPI · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Kaori Takahashi *Kagoshima University Veterinary Teaching Hospital, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan.
Hiroshi Nango *Central Research Institute, Wakunaga Pharmaceutical Co., Ltd., Hiroshima, Japan.
Mitsuyasu Ushijima *Central Research Institute, Wakunaga Pharmaceutical Co., Ltd., Hiroshima, Japan.
Miyuki TakashimaCentral Research Institute, Wakunaga Pharmaceutical Co., Ltd., Hiroshima, Japan.
Masato NakamotoCentral Research Institute, Wakunaga Pharmaceutical Co., Ltd., Hiroshima, Japan.
Toshiaki MatsutomoCentral Research Institute, Wakunaga Pharmaceutical Co., Ltd., Hiroshima, Japan.
Hiroshi JikiharaResearch Administration Department, Wakunaga Pharmaceutical Co., Ltd., Hiroshima, Japan.
Nanami ArakawaLaboratory of Clinical Pathology, Department of Veterinary Medicine, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan.
Shinichiro MakiLaboratory of Clinical Pathology, Department of Veterinary Medicine, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan.
Akira YabukiKagoshima University Veterinary Teaching Hospital, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan.
Yasuyuki EndoKagoshima University Veterinary Teaching Hospital, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan.
Osamu YamatoLaboratory of Clinical Pathology, Department of Veterinary Medicine, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima, Japan.
Wakunaga (Japan) · JPKagoshima University · JPKagoshima University Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Periodontal disease is one of the most common dental health problems in dogs. Clinical studies in humans have shown that aged garlic extract (AGE), which contains stable and water-soluble sulfur-containing bioactive compounds, improves the symptoms of periodontal diseases. Our previous study demonstrated that oral administration of AGE in healthy Beagle dogs at 90 mg/kg/day for 12 weeks had no adverse effects such as hemolytic anemia, which is well known to occur as a result of ingestion of

Indexed as

aged garlic extractdental homecaredoggingival indexhalitosisoral healthoral hygienesalivary cathelicidin

Identifiers

PMID38026667
PMCPMC10658002
OpenAlexW4388425300

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.