Evidence map›Paper›PMID 38026227›Full record

ArticleiScience2023

Short salsalate administration affects cell proliferation, metabolism, and inflammation in polycystic kidney disease.

Anish A Kanhai, Elena Sánchez-López, Thomas B Kuipers, Jan B van Klinken, Kyra L Dijkstra, Inge van der Veen, Hans J Baelde, Xuewen Song, York Pei, Hailiang Mei and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. The Role of Mitochondria in Polycystic Kidney Disease.International journal of molecular sciences · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Anish A KanhaiDepartment of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands.
Elena Sánchez-LópezDepartment of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands.
Thomas B KuipersSequencing Analysis Support Core, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, the Netherlands.
Jan B van KlinkenDepartment of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands.
Kyra L DijkstraDepartment of Pathology, Leiden University Medical Center, Leiden, the Netherlands.
Inge van der VeenDepartment of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands.
Hans J BaeldeDepartment of Pathology, Leiden University Medical Center, Leiden, the Netherlands.
Xuewen SongDivision of Nephrology, University Health Network and University of Toronto, Toronto, ON, Canada.
York PeiDivision of Nephrology, University Health Network and University of Toronto, Toronto, ON, Canada.
Hailiang MeiSequencing Analysis Support Core, Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, the Netherlands.
Wouter N LeonhardDepartment of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands.
Oleg A MayborodaCenter for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, the Netherlands.
Dorien J M PetersDepartment of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands.
Leiden University Medical Center · NLUniversity Health Network · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metabolic reprogramming is a driver of autosomal dominant polycystic kidney disease (ADPKD) progression and a potential therapeutic intervention route. We showed before that the AMP-associated protein kinase (AMPK) activator salsalate attenuates cystic disease progression. Here, we aim to study the early, direct effects of short salsalate treatment in adult-onset conditional

Indexed as

Biological sciencesMetabolomicsOmicsTranscriptomics

Identifiers

PMID38026227
PMCPMC10665819
OpenAlexW4387766319

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.