Evidence map›Paper›PMID 38026177›Full record

ArticleiScience2023

Th1/17 polarization and potential treatment by an anti-interferon-γ DNA aptamer in Hunner-type interstitial cystitis.

Yoshiyuki Akiyama, Kaori Harada, Jimpei Miyakawa, Karl J Kreder, Michael A O'Donnell, Maeda Daichi, Hiroto Katoh, Miyuki Hori, Kensuke Owari, Kazunobu Futami and 5 more

Open access · goldAbstract read
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Animal Models of Hunner-Type Interstitial Cystitis.International journal of urology : official journal of the Japanese Urological Association · 2026
    Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Pathogenic effects ofCurrent research in microbial sciences · 2025
    Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

Yoshiyuki AkiyamaDepartment of Urology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Kaori HaradaTAGCyx Biotechnologies Inc., Tokyo, Japan.
Jimpei MiyakawaDepartment of Urology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Karl J KrederDepartment of Urology, University of Iowa, Iowa City, IA, USA.
Michael A O'DonnellDepartment of Urology, University of Iowa, Iowa City, IA, USA.
Maeda DaichiDepartment of Molecular and Cellular Pathology, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan.
Hiroto KatohDepartment of Preventive Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Miyuki HoriTAGCyx Biotechnologies Inc., Tokyo, Japan.
Kensuke OwariTAGCyx Biotechnologies Inc., Tokyo, Japan.
Kazunobu FutamiTAGCyx Biotechnologies Inc., Tokyo, Japan.
Shumpei IshikawaDepartment of Preventive Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Tetsuo UshikuDepartment of Pathology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Haruki KumeDepartment of Urology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Yukio HommaDepartment of Urology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Yi LuoDepartment of Urology, University of Iowa, Iowa City, IA, USA.
The University of Tokyo · JPTagCyx Biotechnologies (Japan) · JPUniversity of Iowa · USKanazawa University · JPKyorin University · JP

Funding

Inhibition of TLR4 for Treatment of Cystitis PainR01DK111396 · NIDDK · UNIVERSITY OF IOWA · PI LUO, YI · 2017 to 2020
$1.4M
NIDDK NIH HHS R01 DK111396
6 · The paper itself

Abstract

Hunner-type interstitial cystitis (HIC) is a rare, enigmatic inflammatory disease of the urinary bladder with no curative treatments. In this study, we aimed to characterize the unique cellular and immunological factors specifically involved in HIC by comparing with cystitis induced by

Indexed as

DiseaseImmunology

Identifiers

PMID38026177
PMCPMC10663743
OpenAlexW4387849734

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.