Evidence map›Paper›PMID 38026155›Full record

ArticleiScience2023

Changes in neuropeptide large dense core vesicle trafficking dynamics contribute to adaptive responses to a systemic homeostatic challenge.

Matthew K Kirchner, Ferdinand Althammer, Kevin J Donaldson, Daniel N Cox, Javier E Stern

Open access · goldAbstract read
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Navigating Central Oxytocin Transport: Known Realms and Uncharted Territories.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2025
    Review
  5. Neuroendocrine Control of Synaptic Transmission by PHAC-1 inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  6. Neuropeptides: The Evergreen Jack-of-All-Trades in Neuronal Circuit Development and Regulation.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Matthew K KirchnerCenter for Neuroinflammation and Cardiometabolic Diseases, Georgia State University, Atlanta, GA 30303, USA.
Ferdinand AlthammerCenter for Neuroinflammation and Cardiometabolic Diseases, Georgia State University, Atlanta, GA 30303, USA.
Kevin J DonaldsonNeuroscience Institute, Georgia State University, Atlanta, GA 30303, USA.
Daniel N CoxNeuroscience Institute, Georgia State University, Atlanta, GA 30303, USA.
Javier E SternCenter for Neuroinflammation and Cardiometabolic Diseases, Georgia State University, Atlanta, GA 30303, USA.
Georgia State University · US

Funding

Molecular and Computational Dissection of Cold NociceptionR01NS115209 · NINDS · GEORGIA STATE UNIVERSITY · PI GENNADY S CYMBALYUK, Daniel N Cox · 2019 to 2026
$3.5M
Inverse neurovascular coupling in the hypothalamus and its role in positive feedback regulation of Vasopressin neurons in health and diseaseR01HL162575 · NHLBI · GEORGIA STATE UNIVERSITY · PI FILOSA, JESSICA A, STERN, JAVIER E · 2022 to 2025
$2.7M
Calcium-dependent autoregulation of vasopressin neurons in a rodent model of heart failure.K99HL168434 · NHLBI · GEORGIA STATE UNIVERSITY · PI KIRCHNER, MATTHEW · 2023 to 2024
$189k
NHLBI NIH HHS K99 HL168434NHLBI NIH HHS R01 HL162575NINDS NIH HHS R01 NS115209
6 · The paper itself

Abstract

Neuropeptides are packed into large dense core vesicles (LDCVs) that are transported from the soma out into their processes. Limited information exists regarding mechanisms regulating LDCV trafficking, particularly during challenges to bodily homeostasis. Addressing this gap, we used 2-photon imaging in an

Indexed as

BiochemistryBiological sciencesCell biologyCellular neuroscienceFunctional aspects of cell biologyMolecular neuroscienceNatural sciencesNeuroscience

Identifiers

PMID38026155
PMCPMC10654599
OpenAlexW4387740439

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.