Evidence map›Paper›PMID 38026081›Full record

ArticleBJA open2023

Heart rate recovery after orthostatic challenge and cardiopulmonary exercise testing in older individuals: prospective multicentre observational cohort study.

Aaron James, David Bruce, Nicholas Tetlow, Amour B U Patel, Ethel Black, Nicole Whitehead, Anna Ratcliff, Alice Jamie Humphreys, Neil MacDonald, Gayle McDonnell and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BJA open, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 4 institutions in 1 country.

Aaron JamesDepartment of Anaesthesia, University Hospitals Plymouth NHS Trust, Plymouth, UK.
David BruceDepartment of Anaesthesia, Perioperative Medicine and Critical Care, Royal Marsden Hospital, London, UK.
Nicholas TetlowDepartment of Anaesthesia, Perioperative Medicine and Critical Care, Royal Marsden Hospital, London, UK.
Amour B U PatelTranslational Medicine and Therapeutics, William Harvey Research Institute, Queen Mary, University of London, UK.
Ethel BlackDepartment of Anaesthesia, Perioperative Medicine and Critical Care, Royal Marsden Hospital, London, UK.
Nicole WhiteheadDepartment of Anaesthesia, Perioperative Medicine and Critical Care, Royal Marsden Hospital, London, UK.
Anna RatcliffDepartment of Anaesthesia, University Hospitals Plymouth NHS Trust, Plymouth, UK.
Alice Jamie HumphreysDepartment of Anaesthesia, University Hospitals Plymouth NHS Trust, Plymouth, UK.
Neil MacDonaldDepartment of Anaesthesia and Perioperative Medicine, Royal London Hospital, London, UK.
Gayle McDonnellDepartment of Anaesthesia and Perioperative Medicine, Royal London Hospital, London, UK.
Ravishankar RaobaikadyTranslational Medicine and Therapeutics, William Harvey Research Institute, Queen Mary, University of London, UK.
Jeeveththaa ThirugnanasambantharTranslational Medicine and Therapeutics, William Harvey Research Institute, Queen Mary, University of London, UK.
Jeuela I RavindranTranslational Medicine and Therapeutics, William Harvey Research Institute, Queen Mary, University of London, UK.
Nicole WhiteheadDepartment of Anaesthesia, Perioperative Medicine and Critical Care, Royal Marsden Hospital, London, UK.
Gary MintoDepartment of Anaesthesia, University Hospitals Plymouth NHS Trust, Plymouth, UK.
Tom E F AbbottTranslational Medicine and Therapeutics, William Harvey Research Institute, Queen Mary, University of London, UK.
Shaman JhanjiDepartment of Anaesthesia, Perioperative Medicine and Critical Care, Royal Marsden Hospital, London, UK.
Don MillikenDepartment of Anaesthesia, Perioperative Medicine and Critical Care, Royal Marsden Hospital, London, UK.
Gareth L AcklandTranslational Medicine and Therapeutics, William Harvey Research Institute, Queen Mary, University of London, UK.
Royal Marsden Hospital · GBQueen Mary University of London · GBUniversity Hospitals Plymouth NHS Trust · GBRoyal London Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Impaired vagal function in older individuals, quantified by the 'gold standard' delayed heart rate recovery after maximal exercise (HRR Methods: Prospective multicentre cohort study of subjects scheduled for cardiopulmonary exercise testing (CPET) as part of routine care. Before undergoing CPET, heart rate was measured with participants seated for 3 min, before standing for 3 min (HRR Results: A total of 87 participants (mean age: 64 yr [95%CI: 61-66]; 48 (55%) females) completed both tests. Mean heart rate change every 10 s for 1 min after peak heart rate after standing and exercise was significantly correlated ( Conclusion: Prognostically significant heart rate recovery after exhaustive exercise is characterised by quantitative differences in heart rate recovery after orthostatic challenge. These data suggest that orthostatic challenge is a valid, simple test indicating vagal impairment. Clinical trial registration: researchregistry6550.

Indexed as

exerciseheart rate recoveryorthostaticprognostic

Identifiers

PMID38026081
PMCPMC10654531
OpenAlexW4388327830

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.