Evidence map›Paper›PMID 38025783›Full record

ArticleiScience2023

Vpr attenuates antiviral immune responses and is critical for full pathogenicity of SIV

Alexandre Laliberté, Caterina Prelli Bozzo, Christiane Stahl-Hennig, Victoria Hunszinger, Simone Joas, Ulrike Sauermann, Berit Roshani, Antonina Klippert, Maria Daskalaki, Kerstin Mätz-Rensing and 11 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 4 institutions in 2 countries.

Alexandre LalibertéInstitute of Molecular Virology - Ulm University Medical Center, Meyerhofstraße 1, 89081 Ulm, Germany.
Caterina Prelli BozzoInstitute of Molecular Virology - Ulm University Medical Center, Meyerhofstraße 1, 89081 Ulm, Germany.
Christiane Stahl-HennigGerman Primate Center, Kellnerweg 4, 37077 Göttingen, Germany.
Victoria HunszingerInstitute of Molecular Virology - Ulm University Medical Center, Meyerhofstraße 1, 89081 Ulm, Germany.
Simone JoasInstitute of Molecular Virology - Ulm University Medical Center, Meyerhofstraße 1, 89081 Ulm, Germany.
Ulrike SauermannGerman Primate Center, Kellnerweg 4, 37077 Göttingen, Germany.
Berit RoshaniGerman Primate Center, Kellnerweg 4, 37077 Göttingen, Germany.
Antonina KlippertGerman Primate Center, Kellnerweg 4, 37077 Göttingen, Germany.
Maria DaskalakiGerman Primate Center, Kellnerweg 4, 37077 Göttingen, Germany.
Kerstin Mätz-RensingGerman Primate Center, Kellnerweg 4, 37077 Göttingen, Germany.
Nicole Stolte-LeebGerman Primate Center, Kellnerweg 4, 37077 Göttingen, Germany.
Gregory K TharpEmory National Primate Research Center, Emory Vaccine Center and Department of Pathology & Laboratory Medicine, Emory University, Atlanta, GA, USA.
Dietmar FuchsGerman Primate Center, Kellnerweg 4, 37077 Göttingen, Germany.
Prachi Mehrotra GuptaEmory National Primate Research Center, Emory Vaccine Center and Department of Pathology & Laboratory Medicine, Emory University, Atlanta, GA, USA.
Guido SilvestriEmory National Primate Research Center, Emory Vaccine Center and Department of Pathology & Laboratory Medicine, Emory University, Atlanta, GA, USA.
Sydney A NelsonEmory National Primate Research Center, Emory Vaccine Center and Department of Pathology & Laboratory Medicine, Emory University, Atlanta, GA, USA.
Laura ParodiHost-Pathogen Interactions Program, Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX, USA.
Luis GiavedoniHost-Pathogen Interactions Program, Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX, USA.
Steven E BosingerEmory National Primate Research Center, Emory Vaccine Center and Department of Pathology & Laboratory Medicine, Emory University, Atlanta, GA, USA.
Konstantin M J SparrerInstitute of Molecular Virology - Ulm University Medical Center, Meyerhofstraße 1, 89081 Ulm, Germany.
Frank KirchhoffInstitute of Molecular Virology - Ulm University Medical Center, Meyerhofstraße 1, 89081 Ulm, Germany.
German Primate Center · DEUniversität Ulm · DEEmory University · USTexas Biomedical Research Institute · US

Funding

Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
The Southwest National Primate Research Center Supplement- Infrastructure improvements of ABSL2 holding areasP51OD011133 · OD · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI Larry S. Schlesinger · 2012 to 2026
$129.7M
Illumina NovaSeq 6000 High Throughput DNA Sequencer for Emory UniversityS10OD026799 · OD · EMORY UNIVERSITY · PI BOSINGER, STEVEN EDWARD · 2019 to 2019
$985k
NIH HHS P51 OD011132NIH HHS P51 OD011133NIH HHS S10 OD026799
6 · The paper itself

Abstract

The accessory viral protein R (Vpr) is encoded by all primate lentiviruses. Vpr counteracts DNA repair pathways, modulates viral immune sensing, and induces cell-cycle arrest in cell culture. However, its impact

Indexed as

Immune responseImmunityImmunology

Identifiers

PMID38025783
PMCPMC10679897
OpenAlexW4388197696

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.