Evidence map›Paper›PMID 38025520›Full record

ArticleVascular health and risk management2023

The Diagnostic Utility of Natural Killer Cell Subsets in Deep Vein Thrombosis.

Alshaymaa M Alhabibi, Maisa A Wahab, Ahmed Khairy Sakr, Samar M Abd El-Hamid, Mohamed Yahia Zakaria, Azza Ali Althoqapy, Hanaa Mohammed Eid El Sayed, Sammar Ahmed Kasim, Hanan F Ibrahim, Ola I Saleh and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vascular health and risk management, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Alshaymaa M AlhabibiDepartment of Clinical Pathology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.ORCID 0000-0003-3858-4649
Maisa A WahabDepartment of Vascular Surgery, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.ORCID 0000-0001-6190-1230
Ahmed Khairy SakrDepartment of Vascular Surgery, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.
Samar M Abd El-HamidDepartment of Clinical Pathology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.ORCID 0000-0002-5928-2378
Mohamed Yahia ZakariaDepartment of Vascular and EndoVascular Surgery, Faculty of Medicine for Boys, Al-Azhar University, Cairo, Egypt.ORCID 0000-0002-0810-1266
Azza Ali AlthoqapyMedical Microbiology and Immunology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.
Hanaa Mohammed Eid El SayedInternal Medicine Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.ORCID 0000-0001-8513-2333
Sammar Ahmed KasimInternal Medicine Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.ORCID 0000-0001-7477-8833
Hanan F IbrahimMedical Microbiology and Immunology Department, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.
Ola I SalehDepartment of Radio-Diagnosis, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.
Howida A AhmedDepartment of Radio-Diagnosis, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.ORCID 0009-0000-0391-1721
Alaa H SayedHormones Department, Medical Research and Clinical Studies Institute, National Research Centre, Giza, Egypt.
Mahmoud LotfyMolecular Biology Department, Genetic Engineering & Biotechnology Research Institute, University of Sadat City, Sadat City, Minufiya, Egypt.ORCID 0000-0002-1259-290X
Al-Azhar University · EGNational Research Centre · EGUniversity of Sadat City · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Natural killer (NK) cells are important components of adaptive and innate immune responses. NK cell subsets have different functions and may play a role in vascular disorders. This study aimed to evaluate the proportions of NK cells and their subsets to determine whether they can be used as markers of venous thrombosis and to identify whether there was a link between NK cell proportion and citrullinated histone (H3) levels. Patients and Methods: This study included 100 participants divided into Group I (n=50, patients with deep venous thrombosis (DVT)) and Group II (n=50, age- and sex-matched healthy controls). Group I was further categorized into Group Ia (n=25, patients with acute DVT) and Group Ib (n=25, patients with chronic DVT). The proportions of NK cells and their subsets were evaluated by flow cytometry using CD3/CD16/CD56. The levels of citrullinated histones (H3) were estimated using enzyme-linked immunosorbent assay (ELISA). Results: Compared to the control group, DVT patients had a significantly lower proportion of (CD56 dim/CD16+) NK cells, a significantly higher proportion of (CD56-/CD16+) NK cells and a high level of citrullinated histone (H3). Conclusion: NK cell subsets and citrullinated histone (H3) could be used as markers for DVT and as targets for therapeutic drugs to inhibit the formation or progression of thrombosis.

Indexed as

HistonesKiller Cells, NaturalCD56 AntigenFlow CytometryHumansCD56 AntigenHistonescitrullinated histonedeep venous thrombosisnatural killer cellnatural killer cell subsets

Identifiers

PMID38025520
PMCPMC10680478
OpenAlexW4388932407

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.