SynthesisFrontiers in psychiatry2023
Substance use during pregnancy and risk of postpartum depression: a systematic review and meta-analysis.
Synthesis in Frontiers in psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- Early motherhood, early burden: depression among teenage pregnancy and early motherhood in Africa: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2026Pooled it
- Development and predictors of bipolar disorder in children and adolescents with depressive disorders: a systematic review, meta-analysis, and meta-regression.European psychiatry : the journal of the Association of European Psychiatrists · 2025Pooled it
- Risk factors for postpartum depression: an umbrella review.Frontiers in public health · 2025Pooled it
- A Web-Based Intervention for Reducing Sexually Transmitted Infections and Substance Use During Pregnancy: Randomized Controlled Trial.Journal of medical Internet research · 2026Trial
- Article
- Perinatal Insights Into Parenting, Pathways, and Addiction (PIPPA): Protocol for a Longitudinal, Strengths-Based Study in Flanders, Belgium.JMIR research protocols · 2026Article
- Strengthening the standard of care for perinatal substance use disorders: reproductive health provider perspectives on training, integration, and system improvements.Substance abuse treatment, prevention, and policy · 2026Article
- Perinatal substance use among United States veterans and servicemembers: A scoping review of the literature.Translational issues in psychological science · 2026Article
- Perspectives of professionals on the perinatal period as a window of opportunity for change in women with SUD: insights from healthcare, child welfare, substance use, and child protection services.Frontiers in psychiatry · 2026Article
- Article
- Polysocial risk factors and trajectories of antenatal moderate-to-severe depressive symptoms: a retrospective cohort study in Shenzhen, China.BMC medicine · 2025Article
- Personality, Perinatal Anxiety, and Substance Use as Converging Determinants of Post-Partum Depression in South-East Europe.Medicina (Kaunas, Lithuania) · 2025Article
- Smoking During Pregnancy and Its Association with Maternal Health Among Women of Reproductive Age in Alabama: An Analysis Using the Three Delays Model and PRAMS Phase 8 Data.Healthcare (Basel, Switzerland) · 2025Article
- Alcohol, Tobacco and Illicit Drug Use During Pregnancy in the Longitudinal BELpREG Cohort in Belgium Between 2022 and 2024.Journal of clinical medicine · 2025Article
- Opportunities to sustain matricentric models of community and person-centered care for perinatal substance use in the postFrontiers in psychiatry · 2025Review
- Trends in Postpartum Depression by Race, Ethnicity, and Prepregnancy Body Mass Index.JAMA network open · 2024Article
- Cannabis Use during Pregnancy: An Update.Medicina (Kaunas, Lithuania) · 2024Review
- Article
- Potentially modifiable risk and protective factors affecting mental and emotional wellness in pregnancy.Frontiers in human neuroscience · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Postpartum depression (PPD) is a prevalent mental health condition affecting women globally within the first year following childbirth. Substance use during pregnancy has been associated with an increased risk of developing PPD, but the evidence remains inconclusive. This meta-analysis aims to comprehensively assess the effects of different substances on PPD risk, exploring potential modifiers and confounding factors. Objectives: To examine the proportion of PPD among substance users during pregnancy, compared to non-users, and investigate the specific risk associated with different substances (tobacco, alcohol, and non-specified substance use/multiple substance use). Methods: A systematic literature search was conducted from inception to November 2022 using the Web of Science database (Clarivate Analytics), incorporating Web of Science Core Collection, the BIOSIS Citation Index, the KCI-Korean Journal Database, MEDLINE Results: Among the 26 included studies, encompassing 514,441 women, the pooled prevalence of PPD among substance users during pregnancy was 29% (95% CI 25-33). Meta-analyzes revealed an overall odds ratio (OR) of 3.67 (95% CI 2.31-5.85, Conclusion: This meta-analysis provides evidence of an increased risk of PPD among pregnant substance users, particularly those using multiple substances or tobacco. However, caution is needed in interpreting the association with alcohol use due to its non-significant result. Systematic review registration: This study protocol was registered at PROSPERO (registration number: CCRD42022375500).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.