Evidence map›Paper›PMID 38025272›Full record

ArticleBrain communications2023

Active elite rugby participation is associated with altered precentral cortical thickness.

Thomas D Parker, Karl A Zimmerman, Etienne Laverse, Niall J Bourke, Neil S N Graham, Emma-Jane Mallas, Amanda Heslegrave, Henrik Zetterberg, Simon Kemp, Huw R Morris and 1 more

Open access · goldAbstract read
In one paragraph

Article in Brain communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Thomas D ParkerDepartment of Brain Sciences, Imperial College London, London, W12 0BZ, UK.ORCID https://orcid.org/0000-0001-7679-4220
Karl A ZimmermanDepartment of Brain Sciences, Imperial College London, London, W12 0BZ, UK.
Etienne LaverseUCL Institute of Neurology, London, WC1N 3BG, UK.
Niall J BourkeDepartment of Brain Sciences, Imperial College London, London, W12 0BZ, UK.
Neil S N GrahamDepartment of Brain Sciences, Imperial College London, London, W12 0BZ, UK.ORCID https://orcid.org/0000-0002-0183-3368
Emma-Jane MallasDepartment of Brain Sciences, Imperial College London, London, W12 0BZ, UK.ORCID https://orcid.org/0000-0002-4050-0208
Amanda HeslegraveUCL Institute of Neurology, London, WC1N 3BG, UK.
Henrik ZetterbergUCL Institute of Neurology, London, WC1N 3BG, UK.
Simon KempRugby Football Union, Twickenham Stadium, Twickenham, Middlesex TW2 7BA, UK.
Huw R MorrisUCL Institute of Neurology, London, WC1N 3BG, UK.ORCID https://orcid.org/0000-0002-5473-3774
David J SharpDepartment of Brain Sciences, Imperial College London, London, W12 0BZ, UK.
UK Dementia Research Institute · GBUniversity College London · GBKing's College London · GBSahlgrenska University Hospital · SEThe Football Association · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is growing concern that elite rugby participation may negatively influence brain health, but the underlying mechanisms are unclear. Cortical thickness is a widely applied biomarker of grey matter structure, but there is limited research into how it may be altered in active professional rugby players. Cross-sectional MRI data from 44 active elite rugby players, including 21 assessed within 1 week of head injury, and 47 healthy controls were analysed. We investigated how active elite rugby participation with and without sub-acute traumatic brain injury influenced grey matter structure using whole cortex and region of interest cortical thickness analyses. Relationships between cortical thickness and biomarkers of traumatic brain injury, including fractional anisotropy, plasma neurofilament light and glial fibrillary acidic protein, were also examined. In whole-cortex analyses, precentral cortical thickness in the right hemisphere was lower in rugby players compared with controls, which was due to reductions in non-injured players.

Indexed as

cortical thicknessGFAPhead injuryMRIrugby

Identifiers

PMID38025272
PMCPMC10667029
OpenAlexW4387420288

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.